Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.
What people read
Posts online say that Stem cell treatment helps with Heart failure.
What has been studied
- 14In people12 randomised trials
- 17In animals
- 0Only in the lab
What the studies found
Stem cell treatment has been tested in randomised trials in people with Heart failure.
We found 158 published papers on Stem cell treatment and Heart failure. They were published between 2002 and 2026.
14 of them are studies in people (12 randomised trials), 92 are reviews, 17 are studies in animals and 0 are studies only in the lab. 1 paper was retracted.
The most important ones are listed under Sources.
What this means for you: A study in people is not proof that it helps you. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- Intramyocardial injection of allogeneic human induced pluripotent stem cell-derived cardiomyocytes in advanced ischemic heart failure: an early-stage randomized trial.2026 · Nat Med · Randomised trial
- Changes in Circulating Biomarkers in Patients With Ischemic Heart Failure After Treatment With Autologous Mesenchymal Stromal Cells and c-Kit-Positive Cardiac Cells, Alone or in Combination: Results From the Cardiovascular Cell Therapy Research Network CONCERT-HF Clinical Trial.2026 · J Am Heart Assoc · Randomised trial
- PRIME-HFrEF Trial: a randomized, double-blind, multi-dose umbilical cord-derived mesenchymal stem cell regimen for heart failure.2026 · Signal Transduct Target Ther · Randomised trial
- Adipose tissue-derived mesenchymal stromal cell therapy in nonischemic heart failure with reduced ejection fraction - ARIISE study design.2026 · Future Cardiol · Randomised trial
- Design and rationale of CATO, a Phase IIA, randomized, double-blind, placebo-controlled study of single or repeated intravenous administration of umbilical cord-derived mesenchymal stromal cells in ischemic cardiomyopathy.2026 · Am Heart J · Randomised trial
- Results from the SCIENCE and Danish ASC trials using allogeneic mesenchymal stromal cells to treat ischemic heart failure patients.2025 · Regen Med · Randomised trial
- Mesenchymal precursor cells reduce mortality and major morbidity in ischaemic heart failure with inflammation: DREAM-HF.2025 · Eur J Heart Fail · Randomised trial
- Mesenchymal stromal cells to treat patients with non-ischaemic heart failure: Results from SCIENCE II pilot study.2024 · ESC Heart Fail · Randomised trial
- Stem-Cell-Derived Biologic Ventricular Assist Tissue in Heart Failure.2026 · N Engl J Med · Study in people
- Transplantation of mesenchymal stem cells for prevention of acute myocardial infarction induced heart failure: study protocol of a phase III randomized clinical trial (Prevent-TAHA8).2022 · Trials · Study in people
- Mesenchymal Stem Cell-Derived Exosomes: A Tool for Heart Failure Repair - From Molecular Mechanisms to Clinical Potential.2026 · J Inflamm Res · Review
- Clinical landscape of human pluripotent stem cell-derived cardiomyocyte therapy.2026 · Cell Rep Med · Review
- Bench to Bedside: Insights from Large Animal Models and Emerging Clinical Trials of Endogenous Cardiac Regeneration and Repair.2026 · J Cardiovasc Transl Res · Review
- Intracoronary stem cell transplant in ischemic heart disease: a meta-analysis of randomized trials.2026 · Eur Rev Med Pharmacol Sci · Review
- Efficacy and safety of stem cell therapy for myocardial infarction and heart failure: an updated systematic review and meta-analysis of randomized controlled trials.2026 · Syst Rev · Review
- Cells Versus Cell-Derived Signals in Cardiac Regenerative Therapy: A Comparative Analysis of Mechanisms and Clinical Evidence.2025 · Cells · Review
- Transplantation of human umbilical mesenchymal stromal cells attenuates heart failure progression in a rat model.2026 · Cell Transplant · In animals
- Reductions in myocardial interstitial fibrosis are dissociated from LV chamber stiffness in swine with repetitive pressure overload.2026 · Am J Physiol Heart Circ Physiol · In animals
- Cell-based therapies reverse the heart failure-altered right ventricular proteome towards a pre-disease state.2024 · Stem Cell Res Ther · In animals
- Repeat administration of human umbilical cord mesenchymal stem cells improves left ventricular diastolic function in mice with heart failure with preserved ejection fraction.2024 · Biochem Biophys Res Commun · In animals
- Metabolic conditioning enhances human bmMSC therapy of doxorubicin-induced heart failure.2024 · Stem Cells · In animals
- CSF2RB overexpression promotes the protective effects of mesenchymal stromal cells against ischemic heart injury.2023 · Theranostics · In animals
- Prevention of acute myocardial infarction induced heart failure by intracoronary infusion of mesenchymal stem cells: phase 3 randomised clinical trial (PREVENT-TAHA8).2025 · BMJ · RetractedRetracted
- IMPACT OF STEM CELL THERAPY ADDED TO GUIDELINE-DIRECTED MEDICAL THERAPY ON QUALITY OF LIFE IN PATIENTS WITH ISCHEMIC CARDIOMYOPATHY.2026 · Georgian Med News · Other paper
- Modeling Heart Failure With Preserved Ejection Fraction Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.2026 · Circulation · Other paper
- Combined umbilical cord-derived mesenchymal stem cell exosome and cell therapy in heart failure with reduced ejection fraction.2026 · Regen Med · Other paper
- Promising results with stem-cell-derived tissue transplantation in heart failure.2026 · Nat Rev Cardiol · Other paper