Stem cell treatment & Aplastic anaemia

Written based on 28 research studies on PubMed, searched on 2026. nov. 14..

The claim

Posts online say that stem cell treatment helps with aplastic anaemia.

Where research stands

We found 218 published papers on stem cell treatment and aplastic anaemia. They were published between 1998 and 2026. 14 of them are studies in people. 1 of them compared people who got it with a group that did not. 7 were studies in animals, and 2 were only in cells in the lab. 38 papers are reviews that sum up other studies. 37 new studies in people are running or will start soon, say the trial registers. 46 research projects on stem cell treatment for aplastic anaemia are funded and still running.

• 14In people1 with a comparison group
• 7In animals
• 2Only in the lab

What the studies found

We have not summed up these studies in words yet. The most important papers are listed under Sources.

Verdict

Sources

1. Short-Course Ruxolitinib Initiated at Neutrophil Engraftment for Prevention of Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation: A Multicenter, Randomized, Open-Label, Controlled Phase II Trial.2026 · Transplant Cell Ther · Randomised trial
2. A prospective, open, single-arm clinical trial of fludarabine- cyclophosphamide-porcine anti-lymphocyte globulin conditioning combined with matched sibling donor hematopoietic stem cell transplantation in the treatment of severe aplastic anemia.2026 · Clin Exp Med · Study in people
3. Efficacy and safety of ruxolitinib for graft-versus-host disease prophylaxis in patients with aplastic anemia undergoing PBSC-only allogeneic stem cell transplantation: a prospective phase II study.2026 · Exp Hematol Oncol · Study in people
4. Efficacy of a Modified Post-Transplant Cyclophosphamide Regimen for Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients with Severe Aplastic Anemia: A Prospective Study.2024 · Transplant Cell Ther · Study in people
5. Haploidentical Hematopoietic Stem Cell Transplantation in Pediatric Patients with Acquired Hypocellular Bone Marrow Failure.2023 · Transplant Cell Ther · Study in people
6. Comparison of Haploidentical Hematopoietic Stem Cell Transplant With or Without Unrelated Cord Blood Infusion in Severe Aplastic Anemia: Outcomes of a Multicenter Study.2022 · Front Immunol · Study in people
7. Outcomes of Haploidentical Stem Cell Transplantation using Total Body Irradiation (600 cGy) and Fludarabine with Antithymocyte Globulin in Adult Patients with Severe Aplastic Anemia: A Prospective Phase II Study.2020 · Biol Blood Marrow Transplant · Study in people
8. Outcomes of allogeneic haematopoietic stem cell transplantation for patients with severe aplastic anaemia using the porcine antilymphocyte globulin-containing conditioning regimen.2020 · Ann Hematol · Study in people
9. Combination of HLA-Matched Sibling Allogeneic Hematopoietic Stem Cell Transplantation With Unrelated Cord Blood Unit in Patients Aged 35 to 50 Years With Severe Aplastic Anemia: Preliminary Summary of a Single-Arm Trial.2019 · Transplant Proc · Study in people
10. Successful outcomes of second hematopoietic stem cell transplantation with total nodal irradiation and ATG conditioning for graft failure in adult patients with severe aplastic anemia.2018 · Bone Marrow Transplant · Study in people
11. [Allogeneic hematopoietic stem cell transplantation in aplastic anemia: evolution of transplant strategies and updates to the 2024 ASTCT and 2026 ASH guidelines].2026 · Rinsho Ketsueki · Review
12. Isolated gastric Kaposi sarcoma following allogeneic 2 hematopoietic stem cell transplantation: A Case Report and Literature Review.2026 · Front Med (Lausanne) · Review
13. Hematopoietic stem cell transplantation in North Africa: four decades of progress and regional trends (1984-2024).2026 · Transpl Immunol · Review
14. Successful Haploidentical Hematopoietic Stem Cell Transplantation for Chemotherapy-Induced Aplastic Anemia in a Breast Cancer Survivor: A Case Report and Literature Review.2026 · Case Rep Hematol · Review
15. Stem cell transplantation in immuno-hematologic and infectious diseases.2026 · World J Transplant · Review
16. High-dose Cyclophosphamide Without Stem Cell Rescue in Autoimmune Diseases: A Systematic Review.2024 · Eur J Rheumatol · Review
17. Role of Interleukin-10 Overexpressing Mesenchymal Stem Cells in Promoting Bone Marrow Functional Recovery in Aplastic Anemia Mice.2026 · Stem Cells Int · In animals
18. A one-step surface engineering strategy based on PEG-EGCG to improve systemic delivery and survival of transplanted mesenchymal stromal cells.2026 · J Control Release · In animals
19. Use of Post-Transplant Cyclophosphamide in Matched Related and Unrelated Donor Hematopoietic Stem Cell Transplant for Benign Hematological Disorders.2026 · Indian J Hematol Blood Transfus · In animals
20. Efficacy and safety of rabbit ATLG and ATG in allogeneic hematopoietic stem cell transplantation for children with acquired severe aplastic anemia.2025 · Ann Hematol · In animals
21. Frontline Therapy Options for Adults With Newly Diagnosed Severe Aplastic Anemia: Intensive immunosuppressive Therapy Plus Eltrombopag or Matched Sibling Donor Hematopoietic Stem Cell Transplantation?2022 · Transplant Cell Ther · In animals
22. Allogeneic hematopoietic stem cell transplantation in children with aplastic anemia.2015 · Genet Mol Res · In animals
23. Monocyte Galectin-9 is associated with CD8⁺ T-cell dysfunction and early relapse after haploidentical hematopoietic stem cell transplantation.2026 · Biomark Res · In the lab
24. FZD6 mediates the contributing role of miR-199a-5p in the adipogenesis of bone marrow mesenchymal stem cells derived from aplastic anemia.2025 · Sci Rep · In the lab
25. Aplastic anaemia with a large paroxysmal nocturnal haemoglobinuria clone in an adolescent undergoing allogeneic haematopoietic stem cell transplantation.2026 · BMJ Case Rep · Other paper
26. Total nodal irradiation as part of conditioning for salvage hematopoietic stem cell transplantation in aplastic anemia: A case report.2026 · Indian J Cancer · Other paper
27. Factors Associated With Clinical Trial Participation in Adult Hematopoietic Stem Cell Transplantation Recipients: A Center for International Blood and Marrow Transplant Research (CIBMTR) Analysis.2026 · J Natl Compr Canc Netw · Other paper
28. Efficacy of Unrelated Allogeneic Hematopoietic Stem Cell Transplantation in Severe Aplastic Anemia: A Single-Center Retrospective Study.2026 · Int J Med Sci · Other paper