Stem cell treatment & Autism

Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.

What people read

Posts online say that stem cell treatment helps with autism.

What has been studied

• 1In people
• 14In animals
• 8Only in the lab

What the studies found

!Stem cell treatment has been studied in people with autism, but not in randomised trials.

We found 54 published papers on stem cell treatment and autism. They were published between 2012 and 2027.

1 of them are studies in people (0 randomised trials), 28 are reviews, 14 are studies in animals and 8 are studies only in the lab.

The most important ones are listed under Sources.

Sources

1. Three repeated intrathecal injections of allogenic umbilical cord-derived mesenchymal stromal cells in autism spectrum disorder: a Phase I clinical trial.2026 · Stem Cell Res Ther · Study in people
2. Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles as a cell-free approach in autism spectrum disorder: A systematic review and meta-analysis of preclinical studies.2027 · Behav Brain Res · Review
3. Efficacy of stem cell-derived extracellular vesicles in animal models of autism spectrum disorder: a systematic review and meta-analysis.2026 · Front Psychiatry · Review
4. Cord-Derived Stem Cells for Pediatric Autism Spectrum Disorder: Biological Rationale and Source-Specific Trial Design.2026 · Int J Mol Sci · Review
5. Mesenchymal stem/stromal cell-based therapies for autism spectrum disorder: emerging evidence and clinical prospects.2026 · J Transl Med · Review
6. Stem Cell Therapy and Models for Autism Spectrum Disorder: Insights and Research.2026 · Curr Neuropharmacol · Review
7. Human pluripotent stem cell (hPSC)-derived models for autism spectrum disorder drug discovery.2025 · Expert Opin Drug Discov · Review
8. Non-gene-edited neural stem cells reverse neuroinflammation and microbiota dysbiosis in a sprague-dawley rat model of autism spectrum disorder.2026 · Transl Psychiatry · In animals
9. Human Umbilical Cord Blood Mesenchymal Stem Cells Ameliorate Autism-Like Behaviors in a Valproic Acid-Induced Mouse Model via the IGF-1/Akt Signaling Pathway.2026 · Brain Behav · In animals
10. Extracellular vesicles from stem cells rescue cellular phenotypes and behavioral deficits in SHANK3-associated ASD neuronal and mouse models.2026 · Cell Death Dis · In animals
11. Aberrant neural stem cell quiescence is the gateway to autism development linked to Arid1b.2026 · Mol Psychiatry · In animals
12. ‌Dual-target hUCMSCs/EVs therapy for autism spectrum disorder: remodeling gut microbiota and modulating neuroimmune crosstalk in a valproic acid-induced C57BL/6 mice model.2025 · Stem Cell Res Ther · In animals
13. Mesenchymal stem cell-derived extracellular vesicles alleviate autism by regulating microglial glucose metabolism reprogramming and neuroinflammation through PD-1/PD-L1 interaction.2025 · J Nanobiotechnology · In animals
14. Developmental convergence and divergence in human stem cell models of autism.2026 · Nature · In the lab
15. Autism Spectrum Disorder Induced Pluripotent Stem Cells Display Dysregulated Calcium Signaling During Neural Differentiation.2025 · Cells · In the lab
16. Generation of nine induced pluripotent stem cell lines from six young children with autism spectrum disorder and three matched control subjects from the Qatari population.2024 · Stem Cell Res · In the lab
17. Stem-cell derived neurosphere assay highlights the effects of viral infection on human cortical development.2024 · Brain Behav Immun · In the lab
18. An impaired glycolysis induces ATP deficiency and reduced cell respiration in stem cells of patients with autism spectrum disorders.2025 · Sci Rep · Other paper
19. CRISPR-Cas9-generated PTCHD1 2489T>G stem cells recapitulate patient phenotype when undergoing neural induction.2024 · HGG Adv · Other paper
20. An interaction network of mental disorder proteins in neural stem cells.2017 · Transl Psychiatry · Other paper

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