Stem cell treatment & Dilated cardiomyopathy

Written based on 26 research studies on PubMed, searched on 2026. nov. 14..

The claim

Posts online say that stem cell treatment helps with dilated cardiomyopathy.

Where research stands

We found 107 published papers on stem cell treatment and dilated cardiomyopathy. They were published between 2002 and 2026. 6 of them are studies in people. 4 of them compared people who got it with a group that did not. 16 were studies in animals, and 39 were only in cells in the lab. 29 papers are reviews that sum up other studies. 3 new studies in people are running or will start soon, say the trial registers. 20 research projects on stem cell treatment for dilated cardiomyopathy are funded and still running.

• 6In people4 with a comparison group
• 16In animals
• 39Only in the lab

What the studies found

We have not summed up these studies in words yet. The most important papers are listed under Sources.

Verdict

Sources

1. Randomized Comparison of Allogeneic Versus Autologous Mesenchymal Stem Cells for Nonischemic Dilated Cardiomyopathy: POSEIDON-DCM Trial.2017 · J Am Coll Cardiol · Randomised trial
2. Ixmyelocel-T for patients with ischaemic heart failure: a prospective randomised double-blind trial.2016 · Lancet · Randomised trial
3. Effects of intracoronary CD34+ stem cell transplantation in nonischemic dilated cardiomyopathy patients: 5-year follow-up.2013 · Circ Res · Randomised trial
4. Effects of intracoronary stem cell transplantation in patients with dilated cardiomyopathy.2011 · J Card Fail · Randomised trial
5. Allogeneic cardiosphere-derived cells for the treatment of heart failure with reduced ejection fraction: the Dilated cardiomYopathy iNtervention with Allogeneic MyocardIally-regenerative Cells (DYNAMIC) trial.2020 · EuroIntervention · Study in people
6. Comparison of Mesenchymal Stem Cell Efficacy in Ischemic Versus Nonischemic Dilated Cardiomyopathy.2018 · J Am Heart Assoc · Study in people
7. Modeling the contribution of cardiac fibroblasts in dilated cardiomyopathy using induced pluripotent stem cells.2025 · Mol Pharmacol · Review
8. Stem cell therapy for non-ischemic dilated cardiomyopathy: a systematic review and meta-analysis.2024 · Syst Rev · Review
9. [Research progress of human induced pluripotent stem cells in the establishment and application of dilated cardiomyopathy disease model].2024 · Sheng Li Xue Bao · Review
10. The Pathogenic Mechanisms of and Novel Therapies for Lamin A/C-Related Dilated Cardiomyopathy Based on Patient-Specific Pluripotent Stem Cell Platforms and Animal Models.2024 · Pharmaceuticals (Basel) · Review
11. The efficacy of bone marrow mononuclear stem cell transplantation in patients with non-ischemic dilated cardiomyopathy-a meta analysis.2022 · Heart Fail Rev · Review
12. Circular RNA Expression for Dilated Cardiomyopathy in Hearts and Pluripotent Stem Cell-Derived Cardiomyocytes.2021 · Front Cell Dev Biol · Review
13. Generation of an induced pluripotent stem cell line (SSMCi002-A) from a pediatric dilated cardiomyopathy patient carrying heterozygous mutation in the TTN gene.2026 · Stem Cell Res · In animals
14. Infusion of two-dose mesenchymal stem cells is more effective than a single dose in a dilated cardiomyopathy rat model by upregulating indoleamine 2,3-dioxygenase expression.2022 · Stem Cell Res Ther · In animals
15. Trophoblast Stem-Cell-Derived Exosomes Improve Doxorubicin-Induced Dilated Cardiomyopathy by Modulating the let-7i/YAP Pathway.2020 · Mol Ther Nucleic Acids · In animals
16. DMD Pluripotent Stem Cell Derived Cardiac Cells Recapitulate in vitro Human Cardiac Pathophysiology.2020 · Front Bioeng Biotechnol · In animals
17. Therapeutic effects of erythropoietin expressed in mesenchymal stem cells for dilated cardiomyopathy in rat.2019 · Biochem Biophys Res Commun · In animals
18. Human Umbilical Cord Mesenchymal Stem Cells Alleviate Myocardial Endothelial-Mesenchymal Transition in a Rat Dilated Cardiomyopathy Model.2019 · Transplant Proc · In animals
19. Characterisation of the patient-specific induced pluripotent stem cell line UKEi075-A carrying the heterozygous PRKAG2 frameshift variant c.769_770del (p.E257Kfs*15).2026 · Stem Cell Res · In the lab
20. A highly penetrant LMNA R541C variant associated with dilated cardiomyopathy leads to dysregulation in metabolism and proliferation pathways in stem cell-derived cardiomyocytes.2026 · bioRxiv · In the lab
21. Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients with TTN mutations.2026 · Stem Cell Res · In the lab
22. RBM20 variants disrupt Ca2+ handling and metabolism in dilated and non-compaction cardiomyopathy stem cell models.2026 · Signal Transduct Target Ther · In the lab
23. A HEART-WISE: Allogeneic Wharton's Jelly-derived Mesenchymal Stromal Cells' Intracoronary Transplantation in Pediatric Patients with Dilated Cardiomyopathy: The First Case Reports.2026 · BMC Cardiovasc Disord · Other paper
24. A correspondence on efficacy and safety of stem cell therapy in patients with dilated cardiomyopathy.2024 · Int J Surg · Other paper
25. Myogenic Determination and Differentiation of Chicken Bone Marrow-Derived Mesenchymal Stem Cells under Different Inductive Agents.2022 · Animals (Basel) · Other paper
26. Isogenic human pluripotent stem cell disease models reveal ABRA deficiency underlies cTnT mutation-induced familial dilated cardiomyopathy.2022 · Protein Cell · Other paper