Written based on 13 research studies on PubMed, searched on 2026. nov. 11..
The claim
Posts online say that stem cell treatment helps with frontotemporal dementia.
Where research stands
We found 21 published papers on stem cell treatment and frontotemporal dementia in PubMed. They were published between 2015 and 2025. None of them is a study in people. None was a study in animals, and 12 were only in cells in the lab. 6 papers are reviews that sum up other studies. 3 new studies in people are running or will start soon, says the trial register ClinicalTrials.gov.
- 0In people
- 0In animals
- 12Only in the lab
What the studies found
We have not summed up these studies in words yet. The most important papers are listed under Sources.
Verdict
Stem cell treatment has been studied for frontotemporal dementia only in cells in the lab.
Unproven means: it was only tested in animals or cells, or there is too little or mixed data from people. How we rate claims
What this means for you: Results in animals or in cells often do not hold in people. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- Induced pluripotent stem cell models as a tool to investigate and test fluid biomarkers in Alzheimer's disease and frontotemporal dementia.2024 · Brain Pathol · Review
- Human Induced Pluripotent Stem Cell Models of Frontotemporal Dementia With Tau Pathology.2021 · Front Cell Dev Biol · Review
- Modelling frontotemporal dementia using patient-derived induced pluripotent stem cells.2020 · Mol Cell Neurosci · Review
- Concise Review: Modeling Neurodegenerative Diseases with Human Pluripotent Stem Cell-Derived Microglia.2019 · Stem Cells · Review
- Motoneuron Disease: Clinical.2017 · Adv Neurobiol · Review
- Review: Induced pluripotent stem cell models of frontotemporal dementia.2016 · Neuropathol Appl Neurobiol · Review
- Generation of Induced Pluripotent Stem Cells and Neuroepithelial Stem Cells from a Family with the Pathogenic Variant p.Q337X in Progranulin.2025 · Int J Mol Sci · In the lab
- Patient-derived induced pluripotent stem cells with a C9orf72 expansion as a model to study frontotemporal dementia pathologies.2025 · Mol Biol Cell · In the lab
- Sporadic ALS induced pluripotent stem cell derived neurons reveal hallmarks of TDP-43 loss of function.2025 · Nat Commun · In the lab
- Cell autonomous microglia defects in a stem cell model of frontotemporal dementia.2024 · medRxiv · In the lab
- Editorial Note: Genotype-Specific Differences between Mouse CNS Stem Cell Lines Expressing Frontotemporal Dementia Mutant or Wild Type Human Tau.2024 · PLoS One · Other paper
- Neural stem cell homeostasis is affected in cortical organoids carrying a mutation in Angiogenin.2024 · J Pathol · Other paper
- Generation of a human induced pluripotent stem cell line (INEUi001-A) from an amyotrophic lateral sclerosis/frontotemporal dementia patient with a C9ORF72 G4C2 genotype of <2 (GGGGCCG) and 10 repeats.2023 · Stem Cell Res · Other paper
