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Stem cell treatment & Hydrocephalus

Checked 2026. nov. 14. · Hydrocephalus

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Written based on 18 research studies on PubMed, searched on 2026. nov. 14..

The claim

Posts online say that stem cell treatment helps with hydrocephalus.

Where research stands

We found 42 published papers on stem cell treatment and hydrocephalus. They were published between 1989 and 2026. None of them is a study in people. 17 were studies in animals, and 2 were only in cells in the lab. 10 papers are reviews that sum up other studies. 5 research projects on stem cell treatment for hydrocephalus are funded and still running.

  • 0In people
  • 17In animals
  • 2Only in the lab

What the studies found

We have not summed up these studies in words yet. The most important papers are listed under Sources.

Verdict

Unproven

Stem cell treatment has been studied for hydrocephalus in animals, not yet in people.

Unproven means: it was only tested in animals or cells, or there is too little or mixed data from people. How we rate claims

What this means for you: Results in animals or in cells often do not hold in people. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.

Sources

  1. The role of stem cells in the management of neonatal posthemorrhagic hydrocephalus.2024 · Childs Nerv Syst · Review
  2. Intravenous Stem Cell Therapy for High-Grade Aneurysmal Subarachnoid Hemorrhage: Case Report and Literature Review.2019 · World Neurosurg · Review
  3. [Hidrocefalia congénita-neonatal: alternativas terapéuticas a la derivación. Una mirada a la terapia celular].2018 · Cir Cir · Review
  4. Blood-brain barrier and foetal-onset hydrocephalus, with a view on potential novel treatments beyond managing CSF flow.2017 · Fluids Barriers CNS · Review
  5. Neural Stem Cells and Fetal-Onset Hydrocephalus.2017 · Pediatr Neurosurg · Review
  6. Mesenchymal Stem Cells: The Magic Cure for Intraventricular Hemorrhage?2017 · Cell Transplant · Review
  7. Sox2-overexpressing neural stem cells alleviate ventricular enlargement and neurological dysfunction in posthemorrhagic hydrocephalus.2026 · Neural Regen Res · In animals
  8. A 3D SVZonChip Model for In Vitro Mimicry of the Subventricular Zone Neural Stem Cell Niche.2025 · Bioengineering (Basel) · In animals
  9. Ventricular-subventricular zone stem cell niche adaptations in a mouse model of post-infectious hydrocephalus.2024 · Front Neurosci · In animals
  10. Design of a Stem Cell-Based Therapy for Ependymal Repair in Hydrocephalus Associated With Germinal Matrix Hemorrhages.2024 · Stroke · In animals
  11. Generation of Periventricular Reactive Astrocytes Overexpressing Aquaporin 4 Is Stimulated by Mesenchymal Stem Cell Therapy.2023 · Int J Mol Sci · In animals
  12. Different congenital hydrocephalus-associated mutations in Trim71 impair stem cell differentiation via distinct gain-of-function mechanisms.2023 · PLoS Biol · In animals
  13. p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis.2010 · Cell Death Differ · In the lab
  14. Endoscopically harvested stem cells: a putative method in future autotransplantation.2005 · Neurosurgery · In the lab
  15. Neonatal hypocalcemia and hydrocephalus as early manifestations of intermediate osteopetrosis: successful hematopoietic stem cell transplantation despite negative genetic testing: a case report.2026 · Front Endocrinol (Lausanne) · Other paper
  16. Intraventricular administration of SHED-derived mesenchymal stem cells in neonatal post- infectious hydrocephalus: a first-in-human case report.2026 · Childs Nerv Syst · Other paper
  17. Neural stem cell changes and spatial distribution of AQP4 expression in a fetal goat model of obstructive hydrocephalus.2025 · IBRO Neurosci Rep · Other paper
  18. Therapeutic potential of stem cells in subarachnoid hemorrhage.2025 · Neural Regen Res · Other paper

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