Stem cell treatment & Immune thrombocytopenia (ITP)

Written based on 23 research studies on PubMed, searched on 2026. nov. 14..

The claim

Posts online say that stem cell treatment helps with immune thrombocytopenia (ITP).

Where research stands

We found 64 published papers on stem cell treatment and immune thrombocytopenia (ITP). They were published between 1997 and 2026. 4 of them are studies in people. None of them compared people who got it with a group that did not. 6 were studies in animals, and 3 were only in cells in the lab. 13 papers are reviews that sum up other studies. 1 research project on stem cell treatment for immune thrombocytopenia (ITP) is funded and still running.

• 4In people
• 6In animals
• 3Only in the lab

What the studies found

We have not summed up these studies in words yet. The most important papers are listed under Sources.

Verdict

Sources

1. Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial.2024 · Signal Transduct Target Ther · Study in people
2. Role of bone marrow-derived mesenchymal stem cell defects in CD8+ CD28- suppressor T-lymphocyte induction in patients with immune thrombocytopenia and associated mechanisms.2020 · Br J Haematol · Study in people
3. Hematopoetic stem cell transplantation for immune thrombocytopenia and other refractory autoimmune cytopenias.2008 · Autoimmunity · Study in people
4. Haemopoietic stem cell transplantation in the treatment of severe autoimmune diseases 2000.2001 · Ann Rheum Dis · Study in people
5. [Research progress on mesenchymal stem cells and their extracellular vesicles in immune thrombocytopenia].2026 · Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi · Review
6. Case Report: Hematopoietic stem cell transplantation for refractory chronic immune thrombocytopenia in a child.2026 · Front Immunol · Review
7. The hunt for a cure: modern medical approaches for immune thrombocytopenia.2026 · Expert Rev Hematol · Review
8. Innovative strategies for immune thrombocytopenia treatment: immunomodulatory mechanisms and clinical potential of mesenchymal stem cells.2026 · Stem Cell Res Ther · Review
9. Efficacy and Immunomodulating Properties of Eltrombopag in Aplastic Anemia following Autologous Stem Cell Transplant: Case Report and Review of the Literature.2022 · Pharmaceuticals (Basel) · Review
10. The Mechanistic Effects and Clinical Applications of Various Derived Mesenchymal Stem Cells in Immune Thrombocytopenia.2022 · Acta Haematol · Review
11. Activation of the HMGB1-TLR4 pathway impacts the functionality of bone marrow mesenchymal stem cells and disrupts macrophage polarization in immune thrombocytopenia.2024 · Br J Haematol · In animals
12. miRNA-98-5p Targeting IGF2BP1 Induces Mesenchymal Stem Cell Apoptosis by Modulating PI3K/Akt and p53 in Immune Thrombocytopenia.2020 · Mol Ther Nucleic Acids · In animals
13. Mesenchymal stem cells improve platelet counts in mice with immune thrombocytopenia.2019 · J Cell Biochem · In animals
14. All-trans retinoic acid protects mesenchymal stem cells from immune thrombocytopenia by regulating the complement-interleukin-1β loop.2019 · Haematologica · In animals
15. Transplantation of bone-marrow-derived mesenchymal stem cells into a murine model of immune thrombocytopenia.2017 · Blood Coagul Fibrinolysis · In animals
16. Transplantation of adipose-derived mesenchymal stem cells into a murine model of passive chronic immune thrombocytopenia.2012 · Transfusion · In animals
17. Bone marrow mesenchymal stem cell-derived exosomes induce the Th17/Treg imbalance in immune thrombocytopenia through miR-146a-5p/IRAK1 axis.2021 · Hum Cell · In the lab
18. Integrated mRNA and miRNA profiling revealed deregulation of cellular stress response in bone marrow mesenchymal stem cells derived from patients with immune thrombocytopenia.2018 · Funct Integr Genomics · In the lab
19. Mesenchymal stem cells are functionally abnormal in patients with immune thrombocytopenic purpura.2009 · Cytotherapy · In the lab
20. Autoimmune cytopenia after allogeneic haematopoietic stem cell transplantation - A single-center case series.2026 · Transpl Immunol · Other paper
21. Allogenic Hematopoietic Stem Cell Transplant for Refractory Immune Thrombocytopenia.2026 · Pediatr Transplant · Other paper
22. Combined mesenchymal stem cells and telitacicept therapy for Evans syndrome refractory to various immunosuppressive: a case report.2026 · Res Pract Thromb Haemost · Other paper
23. Incidence, Risk Factors, and Treatment of Autoimmune Cytopenia Following Pediatric Allogeneic Hematopoietic Stem Cell Transplantation.2025 · J Transplant · Other paper