Stem cell treatment & Obesity

Written based on 21 research studies on PubMed, searched on 2026. nov. 11..

The claim

Posts online say that stem cell treatment helps with obesity.

Where research stands

We found 156 published papers on stem cell treatment and obesity. They were published between 2001 and 2026. 1 of them is a study in people. 1 of them compared people who got it with a group that did not. 56 were studies in animals, and 17 were only in cells in the lab. 44 papers are reviews that sum up other studies. 4 new studies in people are running or will start soon, say the trial registers. 4 research projects on stem cell treatment for obesity are funded and still running.

• 1In people1 with a comparison group
• 56In animals
• 17Only in the lab

What the studies found

We have not summed up these studies in words yet. The most important papers are listed under Sources.

Verdict

Sources

1. Type 2 diabetes mellitus duration and obesity alter the efficacy of autologously transplanted bone marrow-derived mesenchymal stem/stromal cells.2021 · Stem Cells Transl Med · Randomised trial
2. Mesenchymal stromal cell-based therapies for obesity-associated metabolic complications: Mechanistic insights, translational evidence, and future perspectives.2026 · Biomed Pharmacother · Review
3. Diet and Lipidomics Mediated Regulation of Mesenchymal Stem Cell Function: Diet, Omics and Stem Cell Connection.2026 · Biomolecules · Review
4. Targeted Strategies of Adipose Stem Cells for Metabolic Diseases: Mechanisms and Clinical Translation Challenges.2026 · Stem Cell Rev Rep · Review
5. Influence of Donor Obesity on Adipose-Derived Stem Cell Function and Therapeutic Efficacy.2026 · Cells · Review
6. Mitochondrial Metabolism Governs Spermatogonial Stem Cell Fate Decisions.2026 · Andrology · Review
7. Adipose stem cell-derived exosomes as emerging neurotherapeutics in obesity induced diabetic neuropathy.2026 · Biomed Pharmacother · Review
8. Adipose stem cell-targeted local delivery of forskolin induces de novo beige adipogenesis and adipose tissue browning to combat obesity.2026 · Acta Biomater · In animals
9. Mesenchymal stem cells receive adaptive islet-derived miR-151-containing sEVs to promote β cell compensation in obesity.2026 · Sci Adv · In animals
10. Dental Tissue-Derived Mesenchymal Stem Cells Modulate Mitochondrial and OPG/RANKL Signaling in Obesity-Associated Osteoporosis Under Estrogen-Deficient and Intact Conditions.2026 · Biomedicines · In animals
11. Gut microbiota alteration contributes to bone marrow mesenchymal stem cells connexin43 response to high-fat diet induced obesity in mice.2026 · Int J Obes (Lond) · In animals
12. TREM2 promotes adipogenesis of PDGFR-α+ adipose stem cells but is dispensable for adipose remodeling and metabolic health during diet-induced obesity.2026 · Front Endocrinol (Lausanne) · In animals
13. Brown adipose-derived mesenchymal stromal cells improve sepsis-induced multiorgan dysfunction more than white adipose cells in obese rats.2026 · Cytotherapy · In animals
14. In vitro Modeling of Adipogenesis Using Mesenchymal Stem Cells from Subcutaneous Adipose Tissue to Explore the Cellular and Molecular Mechanisms Underlying Pediatric Obesity and Obesogenic Memory.2026 · Obes Facts · In the lab
15. Adipose-Derived Stem Cells From Human Lumbar Subcutaneous Tissue in Obesity: Inflammatory Microenvironment Promotes Differentiation Capacity.2026 · Stem Cells Int · In the lab
16. Maternal Obesity Programs Adipogenic Commitment in Neonatal Mesenchymal Stem Cells: A Link to Redox-Dependent FOXO1 Signaling.2026 · J Cell Physiol · In the lab
17. Maternal obesity alters adipogenic potential and mitochondrial maximal respiration in infant mesenchymal stem cells.2026 · Front Endocrinol (Lausanne) · In the lab
18. Author Correction: Obesity-associated macrophages dictate adipose stem cell ferroptosis and visceral fat dysfunction by propagating mitochondrial fragmentation.2026 · Nat Commun · Other paper
19. Single-Cell Landscapes of Adipose-Derived Mesenchymal Stem Cells: From Homeostatic Regulators to Obesity-Driven Central Hubs.2026 · Endocr Rev · Other paper
20. Conditioning dose adjustment in obese adult patients with severe aplastic anemia undergoing haploidentical hematopoietic stem cell transplantation: a propensity score-matched analysis.2026 · Bone Marrow Transplant · Other paper
21. Weight-Based Dosing of Calcineurin Inhibitors in Patients with Obesity Undergoing Hematopoietic Stem Cell Transplantation: Blood Concentrations and Clinical Outcomes.2026 · Transplant Cell Ther · Other paper