Stem cell treatment & Peripheral artery disease

Written based on 24 research studies on PubMed, searched on 2026. nov. 14..

The claim

Posts online say that stem cell treatment helps with peripheral artery disease.

Where research stands

We found 101 published papers on stem cell treatment and peripheral artery disease. They were published between 2004 and 2026. 4 of them are studies in people. 1 of them compared people who got it with a group that did not. 16 were studies in animals, and 6 were only in cells in the lab. 63 papers are reviews that sum up other studies. 2 new studies in people are running or will start soon, say the trial registers. 12 research projects on stem cell treatment for peripheral artery disease are funded and still running.

• 4In people1 with a comparison group
• 16In animals
• 6Only in the lab

What the studies found

We have not summed up these studies in words yet. The most important papers are listed under Sources.

Verdict

Sources

1. A novel therapeutic management for diabetes patients with chronic limb-threatening ischemia: comparison of autologous bone marrow mononuclear cells versus allogenic Wharton jelly-derived mesenchymal stem cells.2023 · Stem Cell Res Ther · Randomised trial
2. Wharton's jelly mesenchymal stem cells transplantation for critical limb ischemia in patients with type 2 diabetes mellitus: a preliminary report of phase I clinical trial.2024 · Cell Tissue Res · Study in people
3. Report of a phase 1 clinical trial for safety assessment of human placental mesenchymal stem cells therapy in patients with critical limb ischemia (CLI).2023 · Stem Cell Res Ther · Study in people
4. Topical and intravenous administration of human umbilical cord mesenchymal stem cells in patients with diabetic foot ulcer and peripheral arterial disease: a phase I pilot study with a 3-year follow-up.2022 · Stem Cell Res Ther · Study in people
5. Therapeutic Efficacy of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Critical Limb Ischemia: A Preclinical Systematic Review and Meta-Analysis with Source-Specific Subgroup Analysis.2026 · Ann Vasc Surg · Review
6. The Role of Perivascular Stem Cells in Inflammatory Vascular Diseases: From Immunomodulation to Vascular Regeneration.2026 · J Inflamm Res · Review
7. Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Diabetic Foot Ulcers and Peripheral Artery Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2026 · Int J Low Extrem Wounds · Review
8. Autologous Cell Therapy for Chronic Limb Threatening Ischemia: Towards Personalized Medicine.2026 · Angiology · Review
9. Application of Wharton's Jelly Mesenchymal Stem Cells in Critical Limb Ischemia.2026 · J Endovasc Ther · Review
10. Evaluation of safety and efficacy: a case series of chronic limb-threatening ischemia treated with endovascular revascularization and umbilical cord mesenchymal stem cell therapy.2025 · Stem Cell Res Ther · Review
11. Human induced pluripotent stem cell-derived mesenchymal stromal cells regenerate diabetic ischemic muscle.2026 · Bioeng Transl Med · In animals
12. Targeted KEAP1 disruption enhances antioxidant defense and mesenchymal stromal cell therapy for chronic limb-threatening ischemia.2026 · Mol Ther · In animals
13. Bone Marrow Mesenchymal Stem Cells Overexpressing MicroRNA-126 to Treat Critical Limb Ischemia.2025 · Microrna · In animals
14. Hypercholesterolemia impairs collateral artery enlargement by ten-eleven translocation 1-dependent hematopoietic stem cell autonomous mechanism in a murine model of limb ischemia.2024 · JVS Vasc Sci · In animals
15. Hybrid spheroids containing mesenchymal stem cells promote therapeutic angiogenesis by increasing engraftment of co-transplanted endothelial colony-forming cells in vivo.2023 · Stem Cell Res Ther · In animals
16. Keratose Hydrogel Drives Differentiation of Cardiac Vascular Smooth Muscle Progenitor Cells: Implications in Ischemic Treatment.2023 · Stem Cell Rev Rep · In animals
17. Fibroblast Growth Factor 2-engaged cell spheroid for stem cell therapy: role of Interleukin 8 in the immune-modulatory effectiveness in the critical limb ischemia model.2025 · Stem Cells Transl Med · In the lab
18. Alginate-Encapsulated Mesenchymal Stromal Cells Improve Hind Limb Ischemia in a Translational Swine Model.2024 · J Am Heart Assoc · In the lab
19. Effect of acidosis on adipose-derived stem cell impairment and gene expression.2024 · Regen Ther · In the lab
20. Systemic Transfusion of Human Umbilical Cord-Derived Mesenchymal Stromal Cells - Toward Less Invasive and More Effective Cell Therapy for Severe Peripheral Arterial Disease.2023 · Circ J · In the lab
21. Corrigendum to: Bone Marrow Mesenchymal Stem Cells Overexpressing MicroRNA-126 to Treat Critical Limb Ischemia.2026 · Microrna · Other paper
22. Clinical Trial Landscape of Stem Cell Therapy for Peripheral Arterial Disease.2026 · Stem Cell Rev Rep · Other paper
23. Evaluation of the lower extremity blood supply in no-option critical limb ischemia patients with stem cell transplantation by time maximum intensity projection CT perfusion: A single-centre prospective study.2024 · Vascular · Other paper
24. Stem Cell Therapy: A Possible Role in the Treatment of Patients with Chronic Limb-Threatening Ischemia?2023 · Methodist Debakey Cardiovasc J · Other paper