Stem cell treatment & Pulmonary arterial hypertension

Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.

What people read

Posts online say that stem cell treatment helps with pulmonary arterial hypertension.

What has been studied

• 1In people1 randomised trial
• 32In animals
• 5Only in the lab

What the studies found

!Stem cell treatment has been tested in randomised trials in people with pulmonary arterial hypertension.

We found 74 published papers on stem cell treatment and pulmonary arterial hypertension. They were published between 2005 and 2026.

1 of them are studies in people (1 randomised trials), 19 are reviews, 32 are studies in animals and 5 are studies only in the lab. 1 paper was retracted.

The most important ones are listed under Sources.

Sources

1. Improved cell survival and paracrine capacity of human embryonic stem cell-derived mesenchymal stem cells promote therapeutic potential for pulmonary arterial hypertension.2012 · Cell Transplant · Randomised trial
2. Unraveling the pathogenesis of viral-induced pulmonary arterial hypertension: Possible new therapeutic avenues with mesenchymal stromal cells and their derivatives.2025 · Biochim Biophys Acta Mol Basis Dis · Review
3. The Role of Bone Morphogenetic Protein Receptor Type 2 (BMPR2) and the Prospects of Utilizing Induced Pluripotent Stem Cells (iPSCs) in Pulmonary Arterial Hypertension Disease Modeling.2022 · Cells · Review
4. Stem cell therapy for pulmonary arterial hypertension: An update.2022 · J Heart Lung Transplant · Review
5. Progenitor/Stem Cells in Vascular Remodeling during Pulmonary Arterial Hypertension.2021 · Cells · Review
6. Stem/Progenitor Cells and Pulmonary Arterial Hypertension.2021 · Arterioscler Thromb Vasc Biol · Review
7. Current and emerging therapeutic approaches to pulmonary hypertension.2020 · Rev Cardiovasc Med · Review
8. HO-1-modified umbilical cord MSCs alleviate pulmonary arterial hypertension by reducing inflammation and endothelial dysfunction.2026 · Stem Cells Transl Med · In animals
9. Tracheal delivery of HO-1-modified human umbilical cord-derived mesenchymal stem cells treats pulmonary arterial hypertension by enhancing pulmonary antioxidant and anti-inflammatory responses.2026 · Transl Res · In animals
10. Mitochondrial Transplantation from Bone Marrow Mesenchymal Stromal Cells Combined with Sildenafil Attenuated Vascular Remodeling and Improved Right Ventricular Dysfunction in Experimental Pulmonary Arterial Hypertension.2026 · Int J Mol Sci · In animals
11. Mesenchymal stromal cells alleviate pulmonary arterial hypertension by suppressing pulmonary arterial adventitial fibroblast activation and extracellular matrix remodeling via the SOCS3/STAT3 pathway.2026 · Stem Cell Res Ther · In animals
12. Cardioprotective effects of extracellular vesicles from hypoxia-preconditioned mesenchymal stromal cells in experimental pulmonary arterial hypertension.2025 · Stem Cell Res Ther · In animals
13. Mesenchymal Stem Cell-based Apelin Gene Therapy Improves Pulmonary Artery Remodeling in Monocrotaline-induced Pulmonary Hypertension Through PI3K/AKT/eNOS and ERK1/2 Signaling Pathways.2025 · J Cardiovasc Transl Res · In animals
14. Generation of pulmonary arterial hypertension patient-specific induced pluripotent stem cell lines from three unrelated patients with a heterozygous missense mutation in exon 12, a heterozygous in-frame deletion in exon 3 and a missense mutation in exon 11 of the BMPR2 gene.2021 · Stem Cell Res · In the lab
15. Generation of an induced pluripotent stem cell line (PUMCHi006-A) derived from a patient with pulmonary arterial hypertension carrying heterozygous c.1339 G > A mutation in PTGIS gene.2020 · Stem Cell Res · In the lab
16. Derivation of an induced pluripotent stem cell line (PUMCHi003-A) from a patient with pulmonary arterial hypertension carrying heterozygous mutation in PTGIS gene.2020 · Stem Cell Res · In the lab
17. Induced Pluripotent Stem Cell Model of Pulmonary Arterial Hypertension Reveals Novel Gene Expression and Patient Specificity.2017 · Am J Respir Crit Care Med · In the lab
18. Therapeutic Effects of Umbilical Cord Blood Derived Mesenchymal Stem Cell-Conditioned Medium on Pulmonary Arterial Hypertension in Rats.2015 · J Pathol Transl Med · RetractedRetracted
19. The ALPHA phase 1 study: pulmonary ArteriaL hypertension treated with CardiosPHere-Derived allogeneic stem cells.2024 · EBioMedicine · Other paper
20. Human umbilical cord mesenchymal stem cell-derived treatment of severe pulmonary arterial hypertension.2022 · Nat Cardiovasc Res · Other paper
21. Pulmonary arterial hypertension in pediatric patients undergoing high-dose carboplatin/thiotepa and stem cell transplant.2021 · Pulm Circ · Other paper
22. Echocardiography Monitoring of Pulmonary Hypertension after Pediatric Hematopoietic Stem Cell Transplantation: Pediatric Pulmonary Arterial Hypertension and Pulmonary Veno-Occlusive Disease after Hematopoietic Stem Cell Transplantation.2021 · Transplant Cell Ther · Other paper

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