Új vizsgálatok, publikációk, preprintek és pályázatok ezen a célponton, hónapról hónapra.
Vizsgálat
Expression of TSLP Isoforms in Asthma
2026. aug. 26.· NA · RECRUITING· CTGOV
Publikáció
TSLP impairs mucociliary transport by inhibiting JAK signaling in both central and peripheral airways.
2026. aug. 4.· Pflugers Archiv : European journal of physiology· PUBMED
Publikáció
Tezepelumab Reverses TSLP-Driven Immunometabolic Rewiring in Human cDC2s Underlying Pathogenic Th2 and Dysfunctional Treg Responses.
2026. júl. 31.· Allergy· PUBMED
Publikáció
Chebulinic acid suppresses NF-κB/TSLP signaling axis via ACLY-mediated lipid metabolism reprogramming to ameliorate atopic dermatitis.
2026. júl. 16.· Journal of ethnopharmacology· PUBMED
Vizsgálat
Efficacy of an Anti-TSLP Monoclonal Antibody in the Management of Chronic Bronchial Disease Induced by Bronchiolitis Obliterans Syndrome in Allogeneic Hematopoietic Stem Cells Transplantation Recipients
2026. jún. 24.· PHASE2 · RECRUITING· CTGOV
Vizsgálat
A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)
2026. jún. 2.· PHASE2 · RECRUITING· CTGOV
Publikáció
First-in-human, phase 1 study of CM512, a TSLP/IL-13 bispecific antibody, in healthy volunteers: safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity.
2026. máj. 28.· Frontiers in immunology· PUBMED
Publikáció
Epithelial alarmins TSLP, IL-33, and IL-25 in asthma pathogenesis: mechanistic roles and therapeutic implications.
2026. máj. 26.· Molecular biology reports· PUBMED
Publikáció
Tezepelumab: redefining TSLP blockade in severe asthma through mechanistic precision and translational pharmacology.
2026. ápr. 24.· Frontiers in pharmacology· PUBMED
Publikáció
CM512, a potentially novel IgG1-based bispecific antibody dual-targeting TSLP and IL-13, for the suppression of type 2 inflammation.
2026. ápr. 10.· Journal of translational medicine· PUBMED
Publikáció
Kaempferol-7-O-Glucoside Ameliorates Atopic Dermatitis via the TSLP-Mediated JAK2/STAT5 Signaling Axis.
2026. ápr. 4.· Pharmaceuticals (Basel, Switzerland)· PUBMED
Publikáció
Safety, Tolerability, and Pharmacokinetics of HBM9378 (SKB378/WIN378), a Fully Human IgG1 Monoclonal Antibody Against TSLP After Single Ascending Doses in Chinese Healthy Subjects.
2026. márc. 18.· Drug design, development and therapy· PUBMED
Publikáció
Thymic stromal lymphopoietin (TSLP) - pro-inflammatory cytokine and antimicrobial peptide.
2026. márc. 4.· Biochimica et biophysica acta. Molecular cell research· PUBMED
Publikáció
QX008N, an Anti-TSLP Monoclonal Antibody: Pharmacokinetics, Tolerability, and Immunogenicity in Healthy Chinese Subjects.
2026. márc. 1.· Clinical and translational science· PUBMED
Vizsgálat
A Phase 2 Trial of JKN24011 in COPD
2026. febr. 27.· PHASE2 · COMPLETED· CTGOV
Publikáció
Beyond inhaled medications: precision medicine and biologic therapies targeting the IL-33/TSLP/type 2 axis in COPD.
2026. febr. 5.· Frontiers in immunology· PUBMED
Publikáció
Oxidative stress induced TSLP production via TRPV4 regulates type 2 inflammation and pruritus in MC903 induced atopic dermatitis mouse model.
2026. jan. 31.· Journal of dermatological science· PUBMED
Publikáció
Direct targeting of STAT3 by xanthatin suppresses allergic airway inflammation via inhibition of TSLP release and NK2 cell polarization.
2026. jan. 30.· Journal of ethnopharmacology· PUBMED
Publikáció
The predictive value of combined detection of serum IL-33, TSLP and eosinophils in the treatment effect and exacerbation risk of chronic obstructive pulmonary disease.
2026. jan. 28.· BMC pulmonary medicine· PUBMED
Publikáció
TSLP promotes GATA3-expressing effector regulatory T cells via DC2 derived from transitional DCs.
2026. jan. 27.· Nature immunology· PUBMED
Publikáció
Dupilumab attenuates the expression of TSLP and IL-8 induced by dsRNA and IL-4/IL-13 co-stimulation in human small airway epithelial cells.
2026. jan. 23.· PloS one· PUBMED
Publikáció
Magnolia officinalis Rehder & E. Wilson extract and its main component honokiol alleviate asthma by reducing respiratory inflammation through the TRPV1/NFAT/TSLP pathway.
2026. jan. 16.· Phytomedicine : international journal of phytotherapy and phytopharmacology· PUBMED
Publikáció
Retraction: Effects of microRNA-19b on airway remodeling, airway inflammation and degree of oxidative stress by targeting TSLP through the Stat3 signaling pathway in a mouse model of asthma.
2026. jan. 6.· Oncotarget· PUBMED
Publikáció
Enhanced Alarmin Secretion Exacerbates Neutrophil Extracellular Trap (NET) Formation in Active Psoriasis: Implication of IL-33 and TSLP in Driving NET Formation, Inflammation and Oxidative Stress in Psoriasis.
2026. jan. 6.· Antioxidants (Basel, Switzerland)· PUBMED
Publikáció
Role of Cytokines IL-25, IL-33, and TSLP in the Respiratory Tract Inflammation: Therapeutic Perspectives.
2026. jan. 1.· Biochemistry. Biokhimiia· PUBMED
Publikáció
[THE ROLE OF TSLP IN THE PATHOGENESIS OF ALLERGIC DISEASES AND FUTURE THERAPEUTIC PERSPECTIVES].
2026. jan. 1.· Arerugi = [Allergy]· PUBMED
Publikáció
Verekitug, a Novel Antibody Antagonist to the TSLP Receptor in Adults with Asthma: A 32-Week Randomized Phase 1b Multiple Ascending-Dose Trial.
2025. dec. 24.· Clinical pharmacology and therapeutics· PUBMED
Publikáció
Release of Airway Alarmins IL-33 and TSLP in Paediatric Acute Severe Asthma: A Case-Control Study.
2025. dec. 12.· Acta paediatrica (Oslo, Norway : 1992)· PUBMED
Publikáció
A Bispecific Antibody Blocking Both TSLP and IL-4Rα for the Treatment of Allergic Inflammatory Diseases.
2025. nov. 7.· Cells· PUBMED
Vizsgálat
Study to Evaluate the Safety, Pharmacology and Efficacy of WIN378 in Adults With Moderate or Severe Asthma
2025. júl. 24.· PHASE2 · RECRUITING· CTGOV