Does Tranexamic acid, a medicine used in treating and preventing bleeding problems, reduce the blood loos when it is injected directly into the hip joint after insertion of a total hip prosthesis

Ki vehet részt

• ≥ 18 years
• Undergoing surgery for unilateral total hip arthroplasty
• Able to give ones consent either verbally or written

Ki nem vehet részt

• In treatment with the following anticoagulatia: ADP receptorinhibitors, vitamin-K antagonist(within 5-7 days before the operation). Factor Xa inhibitors, thrombine-inhibitors
• Disseminated intravascular coagulation (DIC) or active thromboembolic disease
• Active cancer disease
• Reduced kidney function (GFR <45 ml/hour)
• Operation performed in general anaesthesia
• Patients who are not able to speak and understand Danish
• Patients who refuse to receive blood products
• Present acute thromboembolic event (DVT, AMI, cerebral infarction, pulmonary embolism)
• Had one of the following type of trauma or surgeries in the affected hip: Hip fractures, periacetabulær osteotomy, femurosteotomy, trochanterostetomi
• Rheumatic arthritis
• Allergi to TXA
• Use of oral anticonceptiva
• Known with thrombophilia
• Participated in a clinical trial within the last 30 days
• Alcoholism and morphinism
• Females: menstruation within the last 12 months