Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome
A legfontosabb adatok
- Ki végzi
- Duke University
- Hol
- Durham (Egyesült Államok)A helyszín megnézése
- Azonosító
- Állapot
- Toboroz
- Résztvevők
- 2800 fő, tervezett
- Kezdés
- 2006. jún.
- Várható befejezés
- 2029. márc.
- A vizsgálat típusa
- Megfigyeléses, 3 csoport
- A regiszteradat frissítve
- 2026. május 29.
Ki vehet részt
- Nem
- Nők és férfiak
- Egészséges önkéntesek
- Nem vehetnek részt
A regiszter feltételei, szó szerint
Mind a 4 feltétel megnézéseKevesebb
Ki vehet részt
- Persistent presence of an antiphospholipid antibody, as defined by one or both of the following criteria:; Medium or high anticardiolipin antibody level in the blood on two or more occasions at least 6 weeks apart; Presence of lupus anticoagulant in the plasma on two or more occasions at least 6 weeks apart
- Presence of clinical symptoms seen in patients with APS, including vascular thrombosis (one or more clinical episodes of arterial, venous, or small vessel thrombosis in any tissue or organ) and/or pregnancy morbidity, defined as any of the following:; One or more unexplained deaths of a morphologically normal fetus at or beyond the 10th week of gestation, with normal fetus morphology documented by ultrasound or direct examination or the fetus; One or more premature births of a morphologically normal baby at or before the 34th week of gestation because of severe pre-eclampsia, eclampsia, or severe placental insufficiency; Three or more unexplained consecutive spontaneous abortions before the 10th week of gestation, with maternal anatomic or hormonal abnormalities and paternal and maternal chromosomal causes excluded
- People who have elevated antiphospholipid antibody levels but do not fully meet clinical criteria for APS, and do have affected family members, will be considered for enrollment
Ki nem vehet részt
- No documented presence of antiphospholipid antibody
Helyszínek itt: Egyesült Államok
- Duke University Medical CenterDurham, Egyesült ÁllamokContact: Thomas L. Ortel, MD, PhD (principal investigator)Résztvevőt keres
A vizsgálatról
Mit akar kideríteni a vizsgálat
Antiphospholipid antibody syndrome (APS) is characterized by the presence of antiphospholipid antibodies, which are proteins in the blood that interfere with the body's ability to perform normal blood clotting. Clinical problems associated with antiphospholipid antibodies include an increased risk for the formation of blood clots in the lungs or deep veins of the legs, stroke, heart attack, and recurrent miscarriages. It is possible that some people with APS have a genetic predisposition for developing the syndrome. This study will use a genetic strategy to identify potential inherited risk factors for the development of APS by recruiting people with APS who have family members also affected by the syndrome or by another autoimmune disorder, such as lupus or rheumatoid arthritis.
A vizsgálat 3 csoportja
- 1
Individuals with APS who also have one or more of their family members affected specifically by APS
- 2
Individuals with APS who also have one or more of their family members affected by another type of autoimmune disorder, such as lupus or rheumatoid arthritis.
- 3
Individuals with APS and no family or no family affected with APS or another autoimmune disorder
Kérdések a vizsgálat csapatának
- Milyen gyakran kell bejárnom, és egy-egy alkalom mennyi ideig tart?
- Megtérítik az utazási költséget?
- Megtarthatom a saját orvosomat?
- Mi történik, ha ki akarok lépni?
Contact the study team: see the registry record → Contacts and Locations
Oldal nyomtatása az orvosomnakAdatok és források
- Regiszteradat
- Szerepel a ClinicalTrials.gov-on.
- Hivatalos cím
- Genetics of Antiphospholipid Antibody Syndrome
- A regiszteradat frissítve
- 2026. május 29.