One-Time DNA Study for Vasculitis

Ki vehet részt

• Diagnostic criteria for Giant Cell Arteritis Age at disease onset >50 years (required)
• New onset or new type of localized pain in the head
• Temporal artery abnormality (i.e. temporal artery tenderness to palpation or decreased pulsation, unrelated to arteriosclerosis of cervical arteries)
• ESR of >40mm in the first hour by the Westergren method
• Abnormal artery biopsy (i.e. temporal artery biopsy showing vasculitis characterized by a predominance of mononuclear cell infiltration or granulomatous inflammation, usually with multinucleated giant cells)
• Large Vessel Vasculitis (LVV) by angiogram or biopsy not explained by something else
• Diagnostic criteria for Takayasu's Arteritis
• Age at disease onset <50 years
• Claudication of extremities
• Decreased brachial artery pulse (one or both arteries)
• Blood pressure difference of >10mm Hg between the arms
• Bruit over subclavian arteries or aorta
• Arteriogram abnormalities compatible with TAK (includes conventional dye angiography or MR angiography or CT angiography)
• Diagnostic criteria for Polyarteritis Nodosa Major criteria (not explained by other causes) felt by investigator to be due to vasculitis
• Arteriographic abnormality
• Presence of granulocyte or mixed leukocyte infiltrate in an arterial wall on biopsy
• Mononeuropathy or polyneuropathy; Minor criteria (not explained by other causes) felt by investigator to be due to vasculitis
• Weight loss > 4 kg
• Livedo reticularis, cutaneous ulcerations, or skin nodules
• Testicular pain or tenderness
• Myalgias
• Diastolic blood pressure > 90 mm Hg
• Elevated BUN or serum creatinine levels
• Ischemic abdominal pain; Isolated cutaneous Polyarteritis Nodosa 1. Biopsy-proven cutaneous PAN
• Diagnostic criteria for Granulomatosis with Polyangiitis (Wegener's) (GPA) and Microscopic Polyangitis (MPA)
• Diagnosis of GPA or MPA. Widely accepted diagnostic criteria, as opposed to classification criteria or definitions, have not been developed for GPA \& MPA
• For diagnosis of GPA meets at least 2 of the following 5 modified ACR criteria:; Nasal or oral inflammation with oral ulcers or nasal discharge with pus or blood; Abnormal chest radiograph with nodules, fixed infiltrates, or cavities; Urinary sediment with microhematuria or red cell casts; Granulomatous inflammation within the wall of an artery or in the perivascular area on biopsy; Antineutrophil cytoplasmic antibody (ANCA) positive by enzyme immunoassay for either PR3- or MPO-ANCA
• For diagnosis of MPA, meets the Chapel Hill Consensus Conference Definition for MPA:; Necrotizing vasculitis, with few or no immune deposits, that affects small vessels (i.e., capillaries, venules, arterioles); Necrotizing arteritis involving small- and medium-sized arteries may be present; Necrotizing glomerulonephritis is very common; Pulmonary capillaritis often occurs
• Diagnostic criteria for Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss)
• Asthma
• Peak peripheral blood eosinophilia of >10% of total WBC
• Peripheral neuropathy attributable to vasculitis
• Transient pulmonary infiltrates on chest imaging studies
• Paranasal sinus abnormalities or nasal polyposis
• Eosinophilic inflammation on tissue biopsy; If patients have 4 of the above 6 criteria but lack clearcut documentation of small vessel vasculitis, they are also eligible for enrollment; General Exclusion Criteria:
• Inability to give informed consent and to sign the consent form
• Enrolled in VCRC protocols 5502, 5503, 5504, 5505, 5506, 5522, or 5523
• Unwilling to provide blood for DNA collection