Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma
A legfontosabb adatok
- Ki végzi
- National Cancer Institute (NCI)
- Hol
- Bethesda (Egyesült Államok)A helyszín megnézése
- Azonosító
- Állapot
- Toboroz
- Résztvevők
- 1000 fő, tervezett
- Kezdés
- 2013. szept. 9.
- Várható befejezés
- 2033. júl. 25.
- A vizsgálat típusa
- Megfigyeléses
- A regiszteradat frissítve
- 2026. november 12.
Ki vehet részt
MI-összefoglaló
A vizsgálat saját részvételi feltételeiből. Gép olvasta ki az oldalon álló regiszterszövegből, ezért tévedhet. Hogy ki vehet részt, azt a lenti regiszterszöveg és a vizsgálat csapata dönti el.
The trial is looking for people with malignant mesothelioma or other cancers that make mesothelin, a protein on tumor cells. They give blood, urine, tumor and fluid samples and are followed over time.
- Életkor
- 2 Years to 100 Years. People with mesothelioma can join from age 2. People with the other cancers must be 18 or older.
- Nem
- All sexes can join.
- A betegség stádiuma
- Malignant mesothelioma, or thymic carcinoma, pancreatic or biliary adenocarcinoma, or lung, gastric or ovarian cancer, or another solid tumor known to express mesothelin. The diagnosis must be confirmed by tissue testing.
- Biomarker vagy leletérték
- For cancers other than mesothelioma, the solid tumor must be known to express mesothelin.
A részvétel fő kizáró okai
- Active serious organ disease that makes a biopsy riskier, such as heart disease, recent heart attack, heart failure or lung problems
- Pregnant women
- Other active medical or mental illness that may raise the risk, as judged by the lead doctor
- Adults unable to give informed consent
A regiszter feltételei, szó szerint
Mind a 8 feltétel megnézéseKevesebb
Ki nem vehet részt
- Active concomitant medical or psychological illnesses that may increase the risk to the participant or in adult participants, inability to obtain informed consent, at the discretion of the principal investigator
- Active symptomatic major organ disorder that would increase the risk of biopsy, including but not limited to ischemic heart disease, recent myocardial infarction, active congestive heart failure, pulmonary dysfunction
- Pregnant women
Egyéb feltételek
- INCLUSION CRITERIA:
- All participants >= 2 years of age with malignant mesothelioma
- All participants >=18 years of age with thymic carcinoma, pancreatic or biliary adenocarcinoma or lung, gastric or ovarian cancers or other solid tumor known to express mesothelin
- Confirmed pathological diagnosis is required
- Ability and willingness of participant to provide informed consent to participation
Nézd meg, megfelelhetsz-e
Magadról válaszolj. Ez nem döntés: hogy részt vehetsz-e, azt csak a vizsgálat csapata mondhatja meg.
- 2 és 100 év között vagy?
Helyszínek itt: Egyesült Államok
- National Institutes of Health Clinical CenterBethesda, Egyesült ÁllamokContact: Cathy I Wagner, R.N.Résztvevőt keres
A vizsgálatról
Mit akar kideríteni a vizsgálat
Background:
A teljes eredeti leírásKevesebb
* Malignant mesothelioma is a malignancy arising from the mesothelial cells of the pleura, peritoneum, pericardium, or tunica vaginalis. * Mesothelioma accounts for 0.10% of deaths annually in the United States. Malignant pleural mesothelioma is the most common of these, comprising of 80% of the cases with an annual incidence of about 2,500 in the United States. * The median survival from diagnosis of pleural mesothelioma is approximately 12 months. The majority of patients present with stage III or IV disease with 85-90% of patients considered unresectable at diagnosis. * Peritoneal mesothelioma has a better prognosis than pleural mesothelioma; nevertheless, patients undergoing therapy for peritoneal mesothelioma have few well-studied treatment options due in large part to the rarity of the disease. * In addition to mesothelioma, mesothelin is highly expressed in several cancers, including pancreatic, biliary adenocarcinomas, gastric and ovarian cancers; mesothelin is also expressed in a significantly larger proportion of thymic carcinoma than thymoma.
Objectives:
-To allow sample acquisition for use in the study of mesothelioma.
Eligibility:
* All participants age greater than or equal to 2 years with malignant mesothelioma OR * All participants greater than or equal to 18 years with thymic carcinoma, pancreatic or biliary adenocarcinoma or lung, gastric or ovarian cancers or other solid tumor known to express mesothelin * Must be able and willing to provide informed consent if 18 or over; parent or guardian must be able and willing to provide consent for patients under the age of 18
Design:
* Up to 1000 subjects will be enrolled. * Patients will be followed to determine the course of disease and to record any treatment received for mesothelioma. * Patients will undergo sampling of blood, urine, tumor and abnormal body fluids for tissue banking. * Studies which may be performed on banked material include genetic and genomic studies, establishment of cell cultures and immunologic studies.
A vizsgálat csoportja
- 1/Eligible cancer diagnosis
Subjects with mesothelioma, thymic carcinoma, pancreatic or biliary adenocarcinoma or lung, gastric or ovarian cancers or other solid tumor known to express mesothelin
Kérdések a vizsgálat csapatának
- Milyen gyakran kell bejárnom, és egy-egy alkalom mennyi ideig tart?
- Megtérítik az utazási költséget?
- Megtarthatom a saját orvosomat?
- Mi történik, ha ki akarok lépni?
Contact the study team: see the registry record → Contacts and Locations
Oldal nyomtatása az orvosomnakAdatok és források
- Regiszteradat
- Szerepel a ClinicalTrials.gov-on.
- Hivatalos cím
- Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma and Other Mesothelin Expressing Cancers
- MI-összefoglaló
- A vizsgálat saját részvételi feltételeiből. Gépi kiolvasás: 2026. november 15.
- Illeszkedési kérdések
- Forrás: NCT01950572: ki vehet részt
- A regiszteradat frissítve
- 2026. november 12.