A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia

MI-összefoglaló

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The trial is looking for adults with healthy corneas, keratoconus, ectasia after LASIK, or Fuchs' corneal dystrophy, and people about to have LASIK or PRK. It tests a new imaging method of the cornea.

Életkor

20 to 75 years. The group with ectasia after LASIK is 20 to 60 years.

Nem

All sexes can join.

A betegség stádiuma

Groups: healthy corneas; mild, moderate or advanced keratoconus; LASIK in the past 12 months without problems; ectasia (thinning and bulging of the cornea) at least 12 months after LASIK; short-sightedness with planned PRK or LASIK; Fuchs' corneal dystrophy at early, mild or advanced stage.

Korábbi kezelés

PRK and LASIK groups cannot have had earlier eye surgery. They cannot use eye medicines except seasonal allergy drops such as ketotifen or artificial tears. The Fuchs' group cannot have had eye surgery that may affect the inner cornea cells, such as cataract surgery.

A részvétel fő kizáró okai

• Narrow eye drainage angles that may close, without an open laser hole in the iris (patent peripheral iridotomy)
• Having sight in only one eye
• Not able to understand the imaging instructions
• PRK and LASIK groups: astigmatism over 2 diopter
• Fuchs' group: any other cornea disorder besides keratoconus

A regiszter feltételei, szó szerint

Nézd meg, megfelelhetsz-e

Magadról válaszolj. Ez nem döntés: hogy részt vehetsz-e, azt csak a vizsgálat csapata mondhatja meg.

• 20 és 75 év között vagy?IgenNem

Mit akar kideríteni a vizsgálat

We have developed novel Brillouin microscopy and we are testing its potential for keratoconus and ectasia diagnostics. We plan to perform axial scans of the cornea in human volunteers in order to compare biomechanical properties of Keratoconus vs. Normal corneas and compare biomechanical properties of post-LASIK ectasia vs. normal corneas.

A vizsgálat 7 csoportja

• Healthy volunteers

  Volunteers with normal corneas

  Kezelés: Brillouin imaging

• Patients with keratoconus

  Patients diagnosed with keratoconus

  Kezelés: Brillouin imaging

• post-LASIK no complications

  Subjects who underwent LASIK refractive surgery with no complications

  Kezelés: Brillouin imaging

• post-LASIK who developed ectasia

  patients who underwent LASIK refractive surgery and developed ectasia as a complications

  Kezelés: Brillouin imaging

• Volunteers to receive PRK surgery

  This group includes patients who have been diagnosed with myopia and have been scheduled to undergo PRK surgery. Patients with high astigmatism \> 2 diopter, prior ocular surgeries, and those patients taking any ocular medications except seasonal allergy medicine such as ketotifen or artificial tears will be excluded.

  Kezelés: Brillouin imaging

• Volunteers to receive LASIK Surgery

  This group includes myopic patients who are scheduled to receive LASIK surgery. Patients with high astigmatism \> 2 diopter, prior ocular surgeries, and those patients taking any ocular medications except seasonal allergy medicine such as ketotifen and artificial tears will be excluded.

  Kezelés: Brillouin imaging

• Patients with Fuch's Endothelial Corneal Dystrophy

  This group includes subjects who are diagnosed with Fuch's corneal dystrophy, at early, mild and advanced stages. The inclusion also extends to subjects with, and without keratoconus. But this exclude patients with any other corneal disorders other than keratoconus, and/or history of ophthalmological surgeries that may affect endothelium cell status, e.g. cataract surgeries.

  Kezelés: Brillouin imaging