Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis

Ki vehet részt

• Healthy volunteers will be recruited to serve as controls for studies on peripheral blood samples
• -Volunteers able to provide consent, or in the case of minors, assent

Ki nem vehet részt

• Active malignancy, infection, or any medical condition that in the opinion of the investigator would warrant exclusion
• Subjects with bleeding diathesis or on anticoagulant medications (e.g. coumadin, heparin, clopidogrel but not including aspirin or NSAIDs) are excluded from participation in nasal brushing or biopsy studies; Reason for early termination; -Withdrawal of consent
• Diagnosis of vasculitis or other autoimmune/autoinflammatory disease, including systemic lupus erythematosus, rheumatoid arthritis, sarcoidosis, mixed connective tissue disease or any overlap autoimmune syndrome
• Active malignancy, infection, or any medical condition that in the opinion of the investigator would warrant exclusion
• Pregnant (by history of last menstrual period) or breast-feeding subjects
• Subjects with bleeding diathesis or taking anticoagulant medications (e.g. coumadin, heparin, clopidogrel but not including aspirin or NSAIDs) are excluded from participating in nasal brushing studies
• Subjects < 3 years of age
• Volunteers < 3 years of age risk
• Inability to provide consent, or in the case of minors, assent

Egyéb feltételek

• INCLUSION CRITERIA SUBJECTS WITH VASCULITIS:; Subjects with known or suspected diagnosis of idiopathic systemic vasculitis will be evaluated either at the outpatient or inpatient unit of the Clinical Center as indicated
• Subjects who fulfill modified versions of the 1990 American College of Rheumatology (ACR) Classification Criteria for GPA and PAN
• Subjects who fulfill the 1990 ACR Classification Criteria for EGPA, GCA, and TAK
• Subjects who fulfill the 2012 Chapel Hill Nomenclature definition for MPA
• Subjects with other suspected systemic or single-organ vasculitides