Sporadic Degenerative Ataxia With Adult Onset: Natural History Study

MI-összefoglaló

A vizsgálat saját részvételi feltételeiből. Gép olvasta ki az oldalon álló regiszterszövegből, ezért tévedhet. Hogy ki vehet részt, azt a lenti regiszterszöveg és a vizsgálat csapata dönti el.

The trial is looking for adults whose ataxia (loss of balance and coordination) keeps getting worse, started after age 40, and does not run in the family. It follows people with MSA-C or with sporadic adult onset ataxia of unknown cause over time.

Életkor

40 Years and older; ataxia must have started after the age of 40 years.

Nem

All sexes can join.

A betegség stádiuma

Ataxia that keeps getting worse. People whose ataxia became severe in less than 12 weeks cannot join.

Korábbi kezelés

People who take anticonvulsant (anti-seizure) drugs long term cannot join.

Biomarker vagy leletérték

Negative genetic tests for SCA1, SCA2, SCA3 and SCA6. Negative tests for FRDA and FMR1 premutation in some cases. Antineuronal antibodies negative if the disease has lasted less than 3 years. Normal vitamin B12, negative VDRL and normal thyroid function.

A részvétel fő kizáró okai

• Similar disorders in parents or other close relatives, or parents who are related by blood
• A known cause of the ataxia, such as stroke, encephalitis, sepsis, heat stroke, alcohol abuse or toxins
• Cancer, chronic diarrhea, unexplained vision loss or insulin-dependent diabetes
• Signs of multiple sclerosis, stroke, bleeding or tumor at the back of the brain on scans
• Other brain scan changes not typical of MSA

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

The key goals of SPORTAX-NHS is to compare the phenotype of multiple system atrophy of cerebellar type (MSA-C) and sporadic adult onset ataxia of unknown aetiology (SAOA) and to determine the rate of disease progression in both groups including determination of the factors that predict the development of MSA-C vs. SAOA, and at which time after onset of ataxia, a reliable distinction between both disorders is possible.

A vizsgálat 2 csoportja

• sporadic adult onset ataxia

  SAOA denotes the non-hereditary degenerative adult-onset ataxia disorders that are distinct from multiple system atrophy (MSA). SAOA is a group of ataxia of unknown etiology characterized by a slowly progressive cerebellar syndrome starting around the age of 50 years. Possibly is accompanied by signs of mild autonomic dysfunction that do not meet the criteria of severe autonomic failure required for a diagnosis of MSA.

• cerebellar multiple system atrophy

  Multiple system atrophy of cerebellar type is a cerebellar syndrome with sporadic onset developing in midlife, with autonomic features of otherwise unexplained bladder dysfunction with or without erectile dysfunction in males, orthostatic hypotension and atrophy of the cerebellum, brainstem, and middle cerebellar peduncles.