Detection of Integrin avb6 in IPF, PSC, and COVID19 Using PET/CT

A regiszterben nem jelölt feltételek

• 1.0 Eligibility Criteria for IPF Patients
• 1.1 Inclusion Criteria
• The following inclusion criteria will be monitored:
• Patient is \>/= 18 years old
• Patient is capable of making an informed decision regarding his/her treatment
• Patient diagnosed with IPF by a pulmonologist according to ATS guidelines
• Patient has high-resolution CT with definite Usual Interstitial Pneumonia (UIP) pattern
• Patient has PFT's within the last 12 months with:
  • FVC\<85% predicted
  • DLCO\<65% predicted
• FEV1/FCV ratio \>70%
• Patient is able to comply with study procedures
  • Scanning Option A OR
  • Scanning Option B
  • 1.2 Exclusion Criteria
  • The following exclusion criteria will be monitored:
• Patient with a serious uncontrolled concurrent medical illness that would limit compliance with study requirements
• Patient has a history of any clinically significant lung disease other than IPF as determined by a pulmonologist
• Patient has had a lung infection of any kind in the last 3 months
• Patient is pregnant or lactating
  • 2.0 Eligibility Criteria for PSC Patients
  • 2.1 Inclusion Criteria
  • The following inclusion criteria will be monitored:
• Patient is \>/= 18 years old
• Patient is capable of making an informed decision regarding his/her treatment
• Patient diagnosed with large duct PSC, based on an abnormal cholangiography as assessed by magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP), and/or percutaneous transhepatic cholangiopancreatography (PTC) in the context of cholestatic liver chemistry
• Patient is able to comply with study procedures
  • Scanning Option C
  • 2.2 Exclusion Criteria
  • The following exclusion criteria will be monitored:
• Patient with a serious uncontrolled concurrent medical illness that would limit compliance with study requirements
• Patient has other causes of liver disease, including secondary sclerosing cholangitis or viral, metabolic, or alcoholic liver disease, as assessed clinically
• Patient has a history of ascending cholangitis within 60 days of screening, as assessed clinically
• Patient has history, current clinical or radiological suspicion, or diagnosis of cholangiocarcinoma, other hepatobiliary malignancy, colorectal cancer, or other abdominal malignancy at any time
• Presence of a percutaneous drain or bile duct stent
• Patient is pregnant or lactating
  • 3.0 Eligibility Criteria for Healthy Controls
  • 3.1 Inclusion Criteria
  • The following inclusion criteria will be monitored:
• Person is \>/= 45 years old
• Person is capable of making an informed decision regarding his/her treatment
• Person is able to comply with study procedures
  • Scanning Option A OR
  • Scanning Option B
  • 3.2 Exclusion Criteria
  • The following exclusion criteria will be monitored:
• Person with a serious uncontrolled concurrent medical illness that would limit compliance with study requirements
• Person has a history of any clinically significant lung disease other than IPF as determined by a pulmonologist
• Person had lung infection of any kind in the last 3 months
• Person is pregnant or lactating
  • 4.0 Eligibility Criteria for COVID-19 patients
  • 4.1 Inclusion Criteria
  • The following inclusion criteria will be monitored:
• Patient is \>/= 18 years old
• Patient is capable of making an informed decision regarding his/her treatment
• Patient with a history of SARS-CoV-2 (active or recovered) infection, based on positive RT-PCR testing
• Recovered COVID-19 patient must show evidence of being non-infectious (per Stanford guideline):
  • Symptomatic, non-immunocompromised outpatients are considered COVID neg after 10 days or 3 days after symptoms resolve, whichever is longer.
  • Severely symptomatic or is immunocompromised outpatients are considered non-infectious after 20 days.
  • or RT-PCR negative x2, spaced \>24 hrs apart
• Patient shows or has shown evidence of pulmonary opacities as visualized on chest radiograph or CT
• Patient is able to comply with study procedures and infection control instructions
  • Recovered COVID 19 patients: Scanning Option A OR
  • Recovered COVID-19 patients: Scanning Option B
  • COVID-19 patients with active infection or no evidence of non-active infection: Scanning Option D
  • 4.2 Exclusion Criteria
  • The following exclusion criteria will be monitored:
• Person with serious uncontrolled concurrent medical illness, such as severe hypoxia, that would limit compliance with study and infection control requirements
• Person with pre-existing fibrosing lung disease (such as but not limited to IPF, NSIP, HP, and sarcoidosis prior to COVID-19 infection).
• Person is pregnant or lactating