Central Nervous System Infections in Denmark
Ennek a vizsgálatnak nincs helyszíne itt: Egyesült Államok.
Egy országban van helyszíne. Válassz országot, hogy lásd a helyszíneket.
Kérdések a vizsgálat csapatának
- Milyen gyakran kell bejárnom, és egy-egy alkalom mennyi ideig tart?
- Megtérítik az utazási költséget?
- Megtarthatom a saját orvosomat?
- Mi történik, ha ki akarok lépni?
Contact the study team: see the registry record → Contacts and Locations
Oldal nyomtatása az orvosomnakA vizsgálat adatai
- Ki végzi
- Aalborg University Hospital
- Azonosító
- NCT03418441
- A regiszteradat frissítve
- 2024. május 16.
- Eredeti leírás
The Danish Study Group of Infections of the Brain is a collaboration between all departments of infectious diseases in Denmark. The investigators aim to monitor epidemiological trends in central nervous system (CNS) infections by a prospective registration of clinical characteristics and outcome of all adult (>17 years of age) patients with community-acquired CNS infections diagnosed and/or treated at departments of infectious diseases in Denmark since 1st of January 2015.A teljes eredeti leírásKevesebb
Danish Study Group of Infections of the Brain: A Nationwide Prospective Observational Cohort Study of All Central Nervous System Infections in Adults at Departments of Infectious Diseases in Denmark
The Danish Study Group of Infections of the Brain is a collaboration between all departments of infectious diseases in Denmark. The investigators aim to monitor epidemiological trends in central nervous system (CNS) infections by a prospective registration of clinical characteristics and outcome of all adult (>17 years of age) patients with community-acquired CNS infections diagnosed and/or treated at departments of infectious diseases in Denmark since 1st of January 2015.
Definitions of central nervous system infections:; For all cases with unproven aetiologies no alternative diagnosis than CNS infection is thought more likely after completed multidisciplinary diagnostic work-up; Viral meningitis inclusion criteria; All patients have to have a clinical presentation consistent with non-bacterial meningitis (e.g. headache, neck stiffness, photo- or phonophobia, fever); and; Cerebrospinal fluid leukocytes>10 cells/ml; Patients with viral meningitis with undetermined pathogen have to have:; CSF leukocytes> 10/mL and no other more probable diagnosis assessed by the local investigator; In case of doubt, patients are discussed with the DASGIB secretary and chair or at meetings; Bacterial meningitis inclusion criteria - All patients have to have a clinical presentation consistent with bacterial meningitis (e.g. headache, neck stiffness, fever, altered mental status); and; Proven bacterial aetiology (CSF or blood culture/DNA based technology or antigen tests); Patients with bacterial meningitis in whom the bacteria cannot not be cultured or identified by DNA-based technologies have to have:; CSF leukocytes> 10/mL and no other more probable diagnosis assessed by the local investigator; In case of doubt, patients are discussed with the DASGIB secretary and chair or at meetings; Encephalitis inclusion criteria - All patients have to have a clinical presentation consistent with encephalitis (e.g. headache, fever, focal neurological deficit, altered mental status >24 hours) as defined by the International Encephalitis Consortium (Venkatesan A et al., Clin Infect Dis 2013; doi:10.1093/cid/cit458.); Encephalitis exclusion criteria; We exclude cases of proven or suspected autoimmune encephalitis; Primary brain abscess inclusion criteria; All patient have a clinical presentation consistent with brain abscess (e.g. headache, focal neurological deficit, mass lesion on cranial imaging); and; Proven microbiological aetiology by culture/DNA-based technology from pus from brain abscess or blood or CSF; or; Aspiration of pus from the brain abscess; or; Response to antimicrobial treatment; or; Tumour ruled out; or; Tumour thought less probable than abscess on MRI using diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) sequences; Lyme neuroborreliosis inclusion criteria; A clinical presentation consistent with neuroborreliosis (e.g. radiculopathy); and; CSF pleocytosis>10 leukocytes/mL; and; Positive intrathecal B.burgdorferi antibody production index; Neurosyphilis inclusion criteria - A clinical presentation consistent with neurosyphilis (e.g. 'encephalitis-like symptoms', dementia, ocular or otogenic syphilis); and either; Positive syphilis serology in serum combined with CSF leukocytes>10/mL; or; CSF syphilis antibodies.