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Neurobiology of Sensory Phenomena in Obsessive-Compulsive Disorder

A legfontosabb adatok

Ki végzi
NYU Langone Health
Hol
New York (Egyesült Államok)A helyszín megnézése
Azonosító
Állapot
Befejeződött
Résztvevők
308 fő vett részt
Kezdés
2018. máj. 5.
Befejezés
2024. jan. 24.
A vizsgálat típusa
Megfigyeléses, 3 csoport
A vizsgált kezelések
  • Tasked based functional MRI (fMRI)
  • Eye Tracking Device
A regiszteradat frissítve
2024. július 26.

Ki vehet részt

Életkor
18 év – 60 év
Nem
Nők és férfiak
Egészséges önkéntesek
Részt vehetnek

A regiszter feltételei, szó szerint

Mind a 13 feltétel megnézéseKevesebb

Ki vehet részt

  • Fluent (speaking and writing) in English; Additional criteria for healthy controls (HC):
  • Lifetime absence of major Axis I diagnosis according to Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 criteria
  • Not taking psychotropic medications
  • No first-degree biological relatives with OCD; Additional criteria for siblings (SIB):
  • First-degree biological sibling of a person with OCD; Additional criteria for OCD patients:
  • Diagnosis of OCD according to DSM-5 criteria

Ki nem vehet részt

  • MRI contraindications such as claustrophobia, ferrous implants, braces, or pacemakers
  • Present or previous diagnosis of psychosis, bipolar disorder, or major developmental disorder (autism spectrum disorder, intellectual developmental disorder) based on DSM-5 criteria
  • Major neurological illness (e.g., self-reported history of organic mental syndromes, head trauma, migraines, seizures, other Central Nervous System (CNS) disease, or other significant medical illness that would make participation unsafe or unfeasible)
  • Any disability or health problem that prevents them from completing study procedures (e.g. back problems, severe carpal tunnel syndrome, impaired vision that is not corrected with glasses or contact lenses, etc.)
  • Present diagnosis of alcohol use disorder or substance use disorder (moderate or severe)
  • Current moderate or high suicidality as assessed through the Mini International Neuropsychiatric Interview (MINI) 7.0.2 suicidality module
  • Positive urine toxicology or pregnancy test

Helyszínek itt: Egyesült Államok

  • New York University School of MedicineNew York, Egyesült Államok

A vizsgálatról

Mit akar kideríteni a vizsgálat

The Research Domain Criteria (RDoC) approach seeks to address the neurobiological mechanisms of sensory symptoms in patients with obsessive-compulsive disorder (OCD) by investigating dimensional components of behavior that more closely align with brain circuitry. This project focuses on the dimensional symptom of sensory phenomena (SP), which are uncomfortable or aversive sensory experiences that drive repetitive behaviors in OCD, including "not just right" sensations, physical urges, and sensations of disgust. SP are very prevalent, occurring in 60-80% of OCD patients, and experienced as highly distressing. Unfortunately, SP are not well addressed by standard treatment approaches, which may be in part because their neurobiological mechanisms are not well understood.

A teljes eredeti leírásKevesebb

This project builds on our preliminary data to (1) investigate the neural mechanisms of SP in large OCD cohort showing the full range of SP severity and (2) probe for familial risk markers in unaffected siblings of patients. For Aim 1, SP will be measured in 100 OCD patients using the Sensory Phenomena Scale. Diffusion and fMRI data will be acquired during rest and fMRI tasks. In order to identify familial risk markers, Aim 2 will compare sensory phenomena and neural circuitry between OCD probands, 50 unaffected biological siblings of OCD patients, and 50 unrelated healthy controls without a family history of Axis 1 disorders.

A vizsgálat 3 csoportja

  • OCD Proband

    Healthy controls (HC, n=50) without a family history of OCD will be matched to SIB.

    Kezelés: Tasked based functional MRI (fMRI) és Eye Tracking Device

  • OCD Siblings

    Healthy controls (HC, n=50) without a family history of OCD will be matched to SIB.

    Kezelés: Tasked based functional MRI (fMRI) és Eye Tracking Device

  • Healthy Controls

    Healthy controls (HC, n=50) without a family history of OCD will be matched to SIB.

    Kezelés: Tasked based functional MRI (fMRI) és Eye Tracking Device

Adatok és források

Regiszteradat
Szerepel a ClinicalTrials.gov-on.
A regiszteradat frissítve
2024. július 26.