Identification of Novel Biomarkers to Aid in the Detection of Occult Cancer in Patients With Venous Thromboembolism

MI-összefoglaló

A vizsgálat saját részvételi feltételeiből. Gép olvasta ki az oldalon álló regiszterszövegből, ezért tévedhet. Hogy ki vehet részt, azt a lenti regiszterszöveg és a vizsgálat csapata dönti el.

The trial is looking for adults with a new blood clot in a deep vein or in the lungs (venous thromboembolism). It studies blood markers that may help find hidden cancer.

Életkor

18 years or older

Nem

All sexes

A betegség stádiuma

A blood clot in the deep veins of the arms, legs or pelvis (iliac veins), and/or in the lungs. It must be found by ultrasound, phlebography, CT scan or angiography.

A részvétel fő kizáró okai

• More than 2 days have passed since the blood clot was diagnosed
• No blood sample taken at the start of the study

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

Venous thromboembolism is a common and serious complication in cancer, and is associated with a substantially increased morbidity and mortality. Furthermore, VTE may be the earliest sign of cancer. Recent studies, however, fail to show a clinical benefit of extended cancer screening in this patient population. Better risk prediction models are therefore warranted to identify VTE patients who would benefit from a rapid and extensive cancer screening. Inflammation and hypercoagulability are considered hallmarks of cancer, and emerging light is being shed on the potential of various markers of inflammation and coagulation in cancer diagnostics and prognostics. Among the inflammatory and thrombotic processes linked to cancer is the neutrophil release of web-like nuclear chromatin (DNA and histones), referred to as neutrophil extracellular traps (NETs). Driven by the tumor environment, NETs have recently been shown to play a central role in tumor progression, metastasis, and tumor-associated thrombosis.

A vizsgálat csoportja

• Venous thromboembolism

  Patients presenting with venous thromboembolism (thrombosis in the deep venous system of upper or lower extremities or iliac veins and/or pulmonary embolism) as detected by ultrasonography, phlebography, computer tomography, or angiography