Benefits of Oxytocin in Obstructive Sleep Apnea (OSA) Patients Using Continuous Positive Airway Pressure (CPAP) Machine

MI-összefoglaló

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The trial is looking for adults with obstructive sleep apnea who use a CPAP breathing machine. It tests whether an oxytocin nose spray lowers the CPAP pressure needed during sleep.

Életkor

18 years or older

Nem

Men and women

A betegség stádiuma

Obstructive sleep apnea treated with CPAP

Korábbi kezelés

People must be willing and able to use CPAP for their sleep apnea.

A részvétel fő kizáró okai

• Not willing or not able to use CPAP
• Other sleep disorders
• Pregnant or breastfeeding women, or women who can get pregnant and will not use birth control during the whole study
• Prisoners, or people held for treatment against their will
• Unable to give consent, for example because of a language barrier

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

This study will investigate if an intra-nasal nose spray of the drug oxytocin can decrease the amount of pressure needed from the automatic Continuous Positive Airway Pressure (CPAP) device while sleeping decreasing some of the harmful effects of low oxygen in people with sleep apnea.

A vizsgálat 2 csoportja

• Visit 1 RandomizationA vizsgált kezelés

  At visit 1subjects will receive one of two interventions: either Oxytocin Intranasal spray (40 IU) or Placebo Intranasal spray. Subjects will be blinded as to which drug they are receiving.

  Kezelés: Oxytocin és Placebo

• Visit 2 Crossover RandomizationA vizsgált kezelés

  At visit 2 subjects will receive the opposite intervention from the one they received at visit 1: either Oxytocin Intranasal spray (40 IU) or Placebo Intranasal spray. Subjects will be blinded as to which drug they are receiving.

  Kezelés: Oxytocin és Placebo