Effects of Cannabidiol on Psychiatric Symptoms, Cognition, and Cannabis Consumption in Cannabis Users With Recent-Onset Psychosis

Ki vehet részt

• DSM-5 diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, and other specified or unspecified schizophrenia spectrum and other psychotic disorder
• Experienced a first psychotic episode within the last 5 years
• Self-reported cannabis use at least twice/week for at least the last 4 weeks
• THCCOOH serum levels of ≥ 5 ng/mL
• Total score ≥45 on the 18-item version of the Brief Psychiatric Rating Scale
• Able to give written informed consent
• Normal or corrected to normal vision
• If medicated, no change in psychiatric medication within the preceding 4 weeks, with no foreseeable changes

Ki nem vehet részt

• Use of any barbiturates, diazepam, diltiazem, verapamil, protease inhibitors, any anticonvulsant medications (including valproate/valproic acid, lamotrigine, carbamazepine, and clobazam), glipizide, glyburide, warfarin, and cyclophosphamide/ ifosfamide, due to potential interaction with CBD at the metabolic level
• DSM-5 diagnosis of Substance Use Disorder other that cannabis or nicotine within the last year (recreational use is not exclusionary)
• Currently undergoing active treatment for Cannabis Use Disorder other than low-level (once/week or less) psychosocial intervention
• Uncontrolled hypertension (resting systolic BP above 150 or diastolic above 95 mm Hg)
• History of or current neurological illness, such as stroke, seizure disorders, neurodegenerative diseases, or organic brain syndrome
• Diabetes
• Significant kidney or liver impairment
• Any chronic or severe infectious disease, including HIV and hepatitis
• Cancer
• Cardiovascular disease, such as history of myocardial infarction and ischemia, heart failure, angina, severe arrhythmias, or EKG abnormalities (Wolf-Parkinson-White syndrome, Complete left bundle branch block, PR interval <120 ms or >200 ms, Prolonged QT interval (corrected) >500 ms, Cardiac arrhythmias as defined by PACs >3 per min or PVCs >1 per min)
• Less than the lower limit of normal hemoglobin and hematocrit at screening
• Elevated transaminase levels >3 times the ULN, accompanied by elevations in bilirubin >2 times the ULN
• Intellectual disability
• Pregnant or lactating
• Suicidal ideation currently or within last 6 months (score of >/= 3 on the Columbia Suicide Severity Rating Scale)