Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD

Ki vehet részt

• Veterans of Post-9/11 military conflicts
• with diagnosis of PTSD based on CAPS-5 related to Post-9/11 military combat

Ki nem vehet részt

• PTSD-inducing trauma exposure occurring within the last 3 months prior to pre-enrollment evaluation
• previous rTMS
• history of epilepsy or seizure disorder, a history of major head trauma,
• any neurologic condition likely to increase risk of seizures,
• moderate to severe substance use disorder in last 3 months or any substance use that puts the participant at increased risk or significant impairment
• stroke, and blood vessel abnormalities in the brain,
• dementia,
• Parkinson's disease, Huntington's chorea, or multiple sclerosis
• a lifetime history of psychotic disorder or bipolar disorder
• inability to stop taking any medication that significantly lowers the seizure threshold
• We will screen for a history of traumatic brain injury and exclude potential participants from the study if they have a history of severe TBI or are at high risk for seizures
• history of seizures
• cardiac pacemaker, implanted medication pumps of any sort that would increase the risk of rTMS
• any current medical condition that could preclude being able to safely participate in TMS treatment,
• use of prescription medication or illegal substances that lower the seizure threshold
• current enrollment in an acute experimental treatment for PTSD or trauma-focused psychotherapy treatment
• brain tumors,
• a high suicide risk
• pregnant or nursing
• metal fragments in the head, or any metal objects in or near the head that cannot be safely removed
• non-English speakers because not all of the screening forms, questionnaires, and tests are available in any language except for English