Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

Egyéb feltételek

• PARTICIPANT INCLUSION CRITERIA:; Aged 18-70 years; Able to provide informed consent; Willing to allow biological samples to be stored for future research; Willing to provide one or more of the following tissues: saliva, urine, blood, blood waste products, adipose tissue, bronchial brushing, and/or BAL samples; Willing to allow genetic testing on collected biological samples; PARTICIPANT EXCLUSION CRITERIA:
• Exclusion Criteria for All Participants; The following exclusion criteria apply to all participants who will provide any of the following samples in-person at the NIH CC: saliva, urine, blood, blood waste products, adipose tissue, bronchial brushing, and/or BAL samples:
• Pregnancy
• Positive testing for hepatitis B virus, hepatitis C virus, or HIV (as determined by serum screening tests or relevant viral quantitative studies.)
• Any condition that requires active medical intervention or monitoring to avert serious danger to the individual s health or wellbeing
• Any condition that, in the opinion of the PI, contraindicates participation in this study; Additional Exclusion Criteria for Individuals Giving Blood for Research
• Hemoglobin < 10 g/dL for healthy female volunteers, < 12 g/dL for healthy male volunteers, or < 6 g/dL for participants with sickle cell disease or other chronic anemias; -Additional Exclusion Criteria for Adipose Tissue Biopsy; Individuals meeting any of the following criteria will be excluded from undergoing adipose tissue biopsy. If the participant no longer meets any of these criteria at a later time, then they will be allowed to undergo this procedure
• Currently taking anticoagulation medication
• Platelets < 100,000/microL
• History of keloid formation (or irregular fibrous tissue formed at the site of a scar or injury)
• History of adverse reactions to lidocaine or other local anesthetics
• Any condition that, in the opinion of the PI, contraindicates this procedure; Use of aspirin (or acetylsalicylic acid) and nonsteroidal anti-inflammatory drugs (NSAIDs) are permitted; -Additional Exclusion Criteria for Bronchoscopy; Individuals meeting any of the following criteria will be excluded from undergoing bronchoscopy. If the participant no longer meets any of these criteria at a later time, then they will be allowed to undergo this procedure
• Prothrombin time (PT) > 1 second above the upper limit of normal (ULN) or international normalized ratio > 1.3
• Partial thromboplastin time (PTT) > 1 second above ULN
• Platelets < 150,000/microL
• Currently taking anticoagulation medication
• Use of aspirin within 2 weeks of the bronchoscopy or NSAIDs within 2 days of the bronchoscopy
• Diagnosis of a pulmonary disorder (eg, asthma, chronic bronchitis, cystic fibrosis, or bronchiectasis)
• Respiratory tract infection within the last 4 weeks
• History of adverse reactions to systemic and/or local anesthetics that will be used for this procedure
• History of cigarette smoking within the past 3 months
• History of chronic opioid use
• History of drug or alcohol abuse
• Post-bronchodilator forced expiratory volume in 1 second (FEV1) < 40% of predicted or pre-bronchodilator FEV1 < 35% of predicted
• Active bronchospasm on physical examination
• History of lidocaine allergy
• Any condition that, in the opinion of the PI, contraindicates this procedure; Co-enrollment guidelines: Participants may be co-enrolled in other studies. However, the PI must be notified of co-enrollment