Acetic Acid for the Detection of Esophageal Neoplasms
Megadott ok: not enough patients enrolled
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A vizsgálat adatai
- Ki végzi
- Coordinación de Investigación en Salud, Mexico
- Azonosító
- NCT04054713
- A regiszteradat frissítve
- 2025. április 24.
- Eredeti leírás
Barrett's esophagus is a complication of chronic gastroesophageal reflux disease that occurs in up to 10% to 15% of patients with this pathology. Well-defined risk factors have been established and are important because they are considered a precancerous lesion (intestinal metaplasia). The conventional diagnostic methods are ineffective in reliably detecting potentially treatable lesions. Investigators propose the use of vital chromoendoscopy with acetic acid using the simplified classification of Portsmouth looking for areas with loss of acetowhitening and taking targeted biopsies to increase the detection of esophageal neoplastic lesions.A teljes eredeti leírásKevesebb
Acetic Acid vs Seattle Protocol for Neoplastic Lesions in Barrett Esophagus
Barrett's esophagus is a complication of chronic gastroesophageal reflux disease that occurs in up to 10% to 15% of patients with this pathology. Well-defined risk factors have been established and are important because they are considered a precancerous lesion (intestinal metaplasia). The conventional diagnostic methods are ineffective in reliably detecting potentially treatable lesions. Investigators propose the use of vital chromoendoscopy with acetic acid using the simplified classification of Portsmouth looking for areas with loss of acetowhitening and taking targeted biopsies to increase the detection of esophageal neoplastic lesions.
Bevonási feltételek: Confirmed histological diagnosis of intestinal metaplasia in follow-up protocol without dysplasia; Patients whose endoscopic image is suggestive of esophageal intestinal metaplasia and is confirmed by histology; Barrett's esophagus minimally 2cm; Patients over 18 years of age who wish to participate in the study; Signed informed consent.
Kizáró feltételek: History of esophageal ablative therapy; Known allergy or intolerance to proton pump inhibitors or acetic acid; Uncontrolled coagulopathy (INR> 1.5 or platelets <50,000); Histological evidence of esophageal adenocarcinoma or known with dysplasia; Evidence of esophageal varices; Los Angeles esophagitis C or D; Pregnancy; No authorization of informed consent.