Motor Unit Number Estimation (MUNE) in Adults With Spinal Muscular Atrophy (SMA)

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• Patients unable to tolerate the assessment by virtue of associated medical conditions, respiratory failure with ventilator dependence, or an obligatory need for orthotics that cannot be removed during the evaluation.
• Patients who are, in the investigator's opinion, mentally or legally incapacitated, preventing informed consent, or is unable to read and understand written material including the consent 3. Patients with a pacemaker or cardiac device
• Subjects with any neurological disorder
• Subjects with chronic medical illness that will interfere with their ability to tolerate the study

Egyéb

• Subjects who are, in the investigator's opinion, mentally or legally incapacitated, preventing informed consent, or is unable to read and understand written material including the consent.

• 1. Adults age 17 to 70 with SMA type 2 or 3. The diagnosis of SMA must be documented by the homozygous deletion of both SMN1 genes on standard genetic tests for the disorder, and the determination of type 2 SMA by history of ability to maintain a sitting position when placed, or type 3 by the ability to stand and walk independently. Wheelchair mobile patients will not be excluded from the study.
  • Interest in participating and the ability to travel to the study site on an agreed upon date on four occasions over a total interval of twenty-four months.
  • Be in good health with the exception of SMA. Assessments will be rescheduled for a later date in the event of any intercurrent illness that might affect performance on the assessment.
• Healthy adults age 17 to 70
• Interest in participating and the ability to travel to the study site