Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

Anesthesia is a drug induced, reversible, comatose state that facilitates surgery and it is widely assumed that cognition returns to baseline after anesthetics have been eliminated. However, many patients have persistent memory impairment for weeks to months after surgery. Cardiac surgery appears to carry the highest risk of postoperative cognitive dysfunction (POCD). These cognitive deficits are associated with increased mortality, prolonged hospital stay and loss of independence. The investigators propose to investigate the role of Dexmedetomidine (DEX) in preventing long-term POCD after cardiac surgery and enhancing early postoperative recovery. It is anticipated that DEX will be the first effective preventative therapy for POCD, improve patient outcomes, and reduce length of stay and healthcare costs.

A vizsgálat 2 csoportja

• Dexmedetomidine Hydrochloride GroupMár használt kezelés, összehasonlításként

  Patients will receive a loading dose of 1.2 μg/kg dexmedetomidine prior to transfer to CVICU over 20-60 min immediately postoperative, followed by continuous infusion of 0.3 μg/kg/h for up to 12 hours or until patient is ready for discharge from CVICU (whichever is earlier). Any additional sedatives necessary at the discretion of ICU.

• Standard of Care GroupNincs vizsgálati kezelés, összehasonlításként

  Standard sedation protocols will be followed at the discretion of the attending physician.