UCSD Image-Guided Cognitive-Sparing Radiosurgery for Intracranial Lesions
A legfontosabb adatok
- Hol
- San Diego (Egyesült Államok)A helyszín megnézése
- Fázis
- 2. fázis
Helyszínek itt: Egyesült Államok
- Moores Cancer CenterSan Diego, Egyesült ÁllamokContact: Sheila MedinaRésztvevőt keres
Kérdések a vizsgálat csapatának
- Milyen gyakran kell bejárnom, és egy-egy alkalom mennyi ideig tart?
- Megtérítik az utazási költséget?
- Megtarthatom a saját orvosomat?
- Mi történik, ha ki akarok lépni?
Contact the study team: see the registry record → Contacts and Locations
Oldal nyomtatása az orvosomnakA vizsgálat adatai
- Ki végzi
- Jona Hattangadi-Gluth
- Azonosító
- NCT04343157
- A regiszteradat frissítve
- 2026. szeptember 8.
- Eredeti leírás
In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing SRS for intracranial lesions, and analyze biomarkers of radiation response. This work will advance the investigators' understanding of neurocognitive changes after brain SRS and help create interventions that preserve cognitive-function in patients with intracranial lesions.A teljes eredeti leírásKevesebb
UCSD Image-Guided Cognitive-Sparing Radiosurgery for Intracranial Lesions: Avoidance of Eloquent White Matter and Hippocampal Regions
In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing SRS for intracranial lesions, and analyze biomarkers of radiation response. This work will advance the investigators' understanding of neurocognitive changes after brain SRS and help create interventions that preserve cognitive-function in patients with intracranial lesions.
Bevonási feltételek: Patients 18 years or older; Eligible for intracranial SRS: Limited brain metastases targets geometrically feasible for SRS (intact or resected tumor bed), meningioma, or cerebral AVM; Eastern cooperative Oncology Group (ECOG) performance status 0-2 (score of 0, no symptoms; 1, mild symptoms; 2, symptomatic, <50% in bed during the day); Ability to answer questions and follow commands via neurocognitive testing; Estimated life expectancy greater than 6 months; Pathologic confirmation of extracerebral tumor site (eg, lung, breast, prostate) from either the primary site or a metastatic lesion if brain metastasis; Willingness/Ability to undergo brain MRI scans; Able to give informed consent.
Kizáró feltételek: Planned chemotherapy during SRS (on the day of SRS); Previous whole brain radiation therapy; Pregnant or nursing women; Women of childbearing potential unwilling to use adequate contraception; Inability to complete a magnetic resonance imaging scan with contrast; Tumor directly invading the critical area to be spared (for example a patient with tumor invading a critical white matter tract; ineligible for cognitive-sparing); Leptomeningeal metastases (ineligible for SRS); Metastases from primary germ cell tumor, small cell carcinoma, or primary CNS lymphoma (ineligible for SRS).