The Effect of Time-Restricted Eating in Cardiometabolic Health
A legfontosabb adatok
- Ki végzi
- University of California, Davis
- Hol
- Davis (Egyesült Államok)A helyszín megnézése
- Azonosító
- Állapot
- Leállítva
- Résztvevők
- 55 fő vett részt
- Kezdés
- 2020. nov. 20.
- Befejezés
- 2024. máj. 20.
- A vizsgálat típusa
- Beavatkozással járó, 2 csoport
- A vizsgált kezelések
- 9 hours daily eating window
- 15 hours daily eating window
- A regiszteradat frissítve
- 2024. augusztus 22.
- Miért állt le
- Funding withdrawn as the principal investigator moved from the USA to the UK
Ki vehet részt
- Életkor
- 21 év – 70 év
- Nem
- Nők és férfiak
- Egészséges önkéntesek
- Nem vehetnek részt
A regiszter feltételei, szó szerint
Mind a 24 feltétel megnézéseKevesebb
Ki vehet részt
- body mass index 30-39.9 kg/m2
- fasting plasma glucose 100-125 mg/dl, or 2h OGTT plasma glucose 140-199 mg/dl or hemoglobin A1C 5.7-6.4%
- self-reported habitual eating period > 15 h per day
Ki nem vehet részt
- use of medications that affect the study outcome measures or increase the risk of study procedures and that cannot be temporarily discontinued (e.g., steroids, alpha or beta adrenergic blockers or agonists, etc.)
- smoking and illegal drug use
- individuals that have performed procedures involving substantial exposure to radiation in the last 12 months
- gastrointestinal or bariatric surgery
- type 2 diabetes or other major chronic disease
- sleep disorder
- cancer in last 5 years
- conditions that render subject unable to complete all testing procedures
- shift worker, recent or expected travel crossing time zones
- fasting >12 h/day more than once a week or vegan
- shift worker, recent or expected travel crossing time zones
- fasting >12 h/day more than once a week or vegan
- > once a week no food intake after 1800 h
- habitually waking up before 0400 h and sleeping before 2230 h
- ≥ 150 min per week of structured exercise
- unstable weight (>5% change the last 2 months)
- pregnant or lactating
- menopause
- unable to grant voluntary informed consent or comply with the study instructions
- individuals who are not yet adults (infants, children, teenagers)
- prisoners
Helyszínek itt: Egyesült Államok
- University of California, DavisDavis, Egyesült ÁllamokNo longer taking part
A vizsgálatról
Mit akar kideríteni a vizsgálat
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no energy intake the rest of the day. In rodents, TRE improves metabolic function without caloric restriction, potentially by activating nutrient sensing mechanisms and effects on circadian oscillations. However, an understanding of the effect of TRE on cardiometabolic health in people is not clear and few studies have evaluated this issue. Accordingly, the investigators propose to conduct a randomized controlled trial in people with obesity and prediabetes to determine the effect of 9 h TRE for 12 weeks, without a change in body weight, on key metabolic outcomes that are risk factors for cardiovascular disease (CVD): 1) multi-organ insulin sensitivity; 2) 24 h metabolic homeostasis and diurnal rhythm; and 3) adipose tissue and skeletal muscle biology. The proposed studies will elucidate the cardiometabolic implications of TRE in people with obesity and prediabetes.
A vizsgálat 2 csoportja
- TRE groupEgyéb csoport
Time-restricted eating group
Kezelés: 9 hours daily eating window
- Control groupEgyéb csoport
Time-unrestricted eating group
Kezelés: 15 hours daily eating window
Adatok és források
- Regiszteradat
- Szerepel a ClinicalTrials.gov-on.
- A regiszteradat frissítve
- 2024. augusztus 22.