GGT and Uric Acid to Predict Gestational Diabetes Mellitus
A legfontosabb adatok
- Ki végzi
- Mount Carmel Health System
- Hol
- Columbus (Egyesült Államok)A helyszín megnézése
- Azonosító
- Állapot
- Visszavonva
- Kezdés
- 2021. jún. 21.
- Befejezés
- 2024. dec. 31.
- A vizsgálat típusa
- Megfigyeléses
- A vizsgált kezelések
- GGT/Uric Acid
- A regiszteradat frissítve
- 2025. június 6.
- Miért állt le
- Principal Investigator left the institution.
Ki vehet részt
- Életkor
- 18 év felett
- Nem
- Csak nők
- Egészséges önkéntesek
- Nem vehetnek részt
A regiszter feltételei, szó szerint
Mind a 8 feltétel megnézéseKevesebb
Ki vehet részt
- Pregnant women between > 9 weeks and < 14.0 weeks gestation
Ki nem vehet részt
- Known history of or current diagnosis of type I or type II diabetes mellitus
- Known liver disease
- Known kidney disease
- Known history of or current diagnosis of gout
- Known history of alcoholism or current alcohol use
- < 18 years of age
- Multiple gestation
Helyszínek itt: Egyesült Államok
- Mount Carmel Health SystemColumbus, Egyesült Államok
A vizsgálatról
Mit akar kideríteni a vizsgálat
Gestational Diabetes Mellitus (GDM) is a common metabolic complication of pregnancy defined as new onset hyperglycemia during gestation. GDM conveys significant risk of morbidity and mortality for both mother and infant. An estimated 268,900 infants were born to mothers with GDM in the USA, accounting for approximately 6.9% of births. Although individual correlations have been found between elevated GGT and uric acid levels and later development of GDM, no research has established and validated combined criteria for GGT and uric acid levels that would lead to their use in identifying women at high risk of GDM in the first trimester.
A teljes eredeti leírásKevesebb
Central Hypothesis: Serum GGT and serum uric acid collected between >9-14.0 weeks gestation will be significantly elevated in women who later develop GDM compared to those who do not. Combined analysis of serum uric acid and GGT levels within the first trimester allows for accurate prediction of the development of GDM.
Study population includes women between 9-14 weeks gestation undergoing a standard first trimester blood draw. Additional blood will be drawn during the standard blood draw to assess GGT and uric acid levels. Research participants will be tracked afterwards to determine whether they tested positive for gestational diabetes during the standard testing process which typically occurs at 24-28 weeks gestation. The data will then be analyzed to estimate the sensitivity, specificity, positive and negative predictive values of the first trimester GGT and uric acid tests. The GGT and uric acid levels which maximize the area under the receiver-operator characteristic curve will be identified.
A vizsgálat csoportja
- First Trimester Prenatal Visit
Women attending an initial first trimester prenatal visit who will be undergoing a standard blood draw.
Kezelés: GGT/Uric Acid
Adatok és források
- Regiszteradat
- Szerepel a ClinicalTrials.gov-on.
- Hivatalos cím
- Association of Elevated Serum Gamma Glutamyl Transferase (GGT) and Uric Acid at 9-14 Weeks Gestation With the Development of Gestational Diabetes Mellitus (GDM)
- A regiszteradat frissítve
- 2025. június 6.