Evaluation of the Response of Itraconazole and Terbinafine Therapy in Subjects With Crohn's Disease

Ki vehet részt

• Subjects with endoscopy/radiology confirmation of active disease within 6 months prior to enrolment
• Mild to moderate active CD defined by the HBI score of ≥ 5 to ≤ 16 at baseline
• Female of childbearing potential must have a negative urine pregnancy test at screening and at randomization baseline Visit 2. Women are considered not of childbearing potential if they either:
• Have had a hysterectomy or tubal ligation prior to baseline visit or
• Are postmenopausal defined as no menses for 12 months or a FSH level (if available) in the menopausal range
• Women of childbearing potential must agree to use an effective double method of birth control throughout the study: barrier method (e.g. male or female condoms, spermicides, sponges, foams, jellies, and diaphragm) in combination with other methods of contraception including implantable contraceptives, injectable contraceptives, oral contraceptives, transdermal contraceptives, intrauterine devices, abstinence, or a sterile sexual partner
• Subjects with the capacity to provide informed consent

Ki nem vehet részt

• Subjects on medications which interact with itraconazole: methadone, pimozide, quinidine or other CYP3A4 inhibitors
• Use of steroid greater than 20 mg/day
• Change of steroid dosage in the 2 weeks prior to enrolment
• Change in CD therapy:; The Anti-TNFs, anti-integrins, anti-IL12/23 in the 4 months prior to enrolment; Thiopurines or methotrexate (MTX), in the 2 months prior to enrolment
• Contraindication to the use of itraconazole including congestive heart failure, ventricular dysfunction, ventricular arrhythmia, or negative inotropic state
• Subject with a known hypersensitivity to itraconazole, terbinafine, or any of their excipients
• Subjects with elevated or abnormal liver enzymes (ALT/AST>3 ULN) or patients with pre-existing chronic or active liver disease at screening
• Subject with renal impairment (creatinine clearance ≤ 50 mL/min using Cockcroft-Gault equation)
• Subject with a current diagnosis of ulcerative colitis (UC)
• Female subject who is pregnant, planning to become pregnant during the study, or breastfeeding
• Positive C. difficile toxin test at screening
• Participation in other clinical trial within 30 days of signing the Information and Consent Form (ICF)