Comparison Between Two Durations of Antibiotherapy for Non-surgically-treated Diabetic Foot Osteomyelitis (CHRONOS-2)

Ki vehet részt

• Patient aged ≥ 18 years
• Informed, written consent obtained from patient
• Patient having the rights to Frenc social insurrance
• For women of childbearing potential : any effective contraceptive is required
• Type 1 or 2 diabetic patients
• Diabetic patients treated non-surgically for an osteomyelitis of the forefoot affecting only one osteoarticular part/radial supported by adequate diagnostic imaging and bone biopsy performed through uninfected tissue
• Two peripheral pulses or transcutaneous oxygen tension measurement (TcPO2 > 30mmHg) or ankle brachial index (ABI > 0.9)
• Patient without antibiotherapy during 2 weeks before D1
• Glycated hemoglobin (HbA1C) < 12% ( measured maximum 2 months before D1)
• Use of offloading boot for diabetic foot is feasible

Ki nem vehet részt

• Bone fragmentation, articular destruction requiring bone resection or amputation
• Other drug-drug interaction that contraindicated the full course of antibiotics
• Contraindication for the full course of antibiotics (allergy or based on RCP)
• Patient undergoing radiotherapy of chimiotherapy for malignant neoplasms
• Hepatic insufficiency (ASAT and/or ALAT > 3 times the normal level)
• Any disease or behaviour making impossible to follow the protocol or difficult to interpret the results
• Any disease or context making difficult to allow regular monitoring of the patient
• Gangrene
• More than one osteoarticular part/radial affected
• Contraindication for the use of offloading boot
• Contraindication for bone biopsy
• Charcot foot
• Participation in other interventional research during the study
• Curator or guardianship of patient placed under judicial protection
• Pregnancy or lactating women