Immediate Prescription of a Hypouricemic Treatment, Febuxostat, Compared to Its Delayed Administration

Ki vehet részt

• Patients with an attack of gout, diagnosed immediately or less than 5 days old. Gout is defined according to American-European criteria (Appendix 3)
• Attack of gout affecting one (or more) peripheral joint (s) whatever (s) it (s):; Either a first crisis,; Either a new attack of a gout not treated with a hypo-uricemic or for which the hypo-uricemic treatment has not been taken for at least 6 months
• Uricemia ≥ 420 µmol / l, including under a diuretic (dosage carried out within 10 days before inclusion),
• Age ≥ 18 years old,
• Patient with a creatinine clearance ≥ 30 ml / min (dosage carried out within 10 days before inclusion),
• Patient having read and understood the information letter and signed the consent form,
• Affiliation to a social security scheme,
• Woman of childbearing potential with effective contraception according to WHO definition (estrogen-progestins or intrauterine device or tubal ligation for more than 1 month and to be continued for at least 5 weeks after the last dose of the drug. ) and a negative urine pregnancy test on inclusion and throughout the duration of the study Where Postmenopausal woman: amenorrhea not medically induced for at least 12 months before the inclusion visit

Ki nem vehet részt

• Patient who has received an organ or marrow transplant,
• Person on Naproxen, mercaptopurine, azathioprine, Glycuronidation inhibitors and inducers, theophylline, macrolides, HMG Co-A reductase inhibitors and / or diuretic in combination with an ACE inhibitor or ARAII,
• Participating patient who participated in the month preceding inclusion in another interventional drug trial
• Known contraindication to ADENURIC 80 mg film-coated tablet: hypersensitivity to the active substance (febuxostat) or to one of the excipients,
• Poor understanding of the project due to neurological disease or lack of French practice,
• Any history of pre-existing major cardiovascular disease (myocardial infarction, stroke, unstable angina, etc.), metabolic, endocrine, psychiatric or cancerous in uncontrolled development,
• Renal failure defined by creatinine clearance <30 ml / min,
• Hepatic disease defined by an increase to more than 2 times the normal of transaminases, alkaline phosphatases, to more than 3 times the normal of gamma-GT,
• Person with rare hereditary disorders of galactose intolerance, lactase deficiency or glucose / galactose malabsorption
• Patients under the age of 18,
• Pregnant woman or likely to be in the absence of effective contraception (Women of childbearing age should have a negative urine pregnancy test),
• Stop taking a hypouricemic agent for less than 6 months,
• Non-weaned alcoholism,
• Crisis more than 5 days old,
• Breastfeeding woman
• Person deprived of liberty by an administrative or judicial decision,
• Person placed under judicial protection, guardianship or curatorship,