Remote Ischemic Conditioning, Bimanual Skill Learning, and Corticospinal Excitability
A legfontosabb adatok
- Ki végzi
- East Carolina University
- Hol
- Greenville (Egyesült Államok)A helyszín megnézése
- Azonosító
- Állapot
- Befejeződött
- Résztvevők
- 51 fő vett részt
- Kezdés
- 2021. dec. 18.
- Befejezés
- 2025. máj. 30.
- A vizsgálat típusa
- Beavatkozással járó, 2 csoportAz egyik csoport színlelt kezelést kap, összehasonlításként.
- A vizsgált kezelések
- Remote Ischemic Conditioning (RIC)
- Sham conditioning
- Hand Arm Bimanual Intensive Therapy (HABIT)
- Bimanual Cup Stacking Training
- Balance training
- A regiszteradat frissítve
- 2025. július 16.
Ki vehet részt
- Életkor
- 6 év – 16 év
- Nem
- Nők és férfiak
- Egészséges önkéntesek
- Nem vehetnek részt
A regiszter feltételei, szó szerint
Mind a 5 feltétel megnézéseKevesebb
Ki vehet részt
- Children diagnosed with unilateral cerebral palsy, ages 6-16 years
- Manual Ability Classification System (MACS) levels I-III
- Ability to complete a stack of 3 cups in 2 minutes
- Mainstream in school and has sufficient cognition to follow the experiment instructions
Ki nem vehet részt
- Children with other developmental disabilities such as autism, developmental coordination disorders, etc; Children with absent active motor threshold; Children with cognitive deficits or communication problem; Children with known cardiorespiratory and vascular dysfunctions; Children with metabolic disorders, neoplasm, hydrocephalus; Children who are receiving other adjunct therapies such as rTMS and tDCS; Children with seizures and on anti-seizure medications; Children with metal implants and incompatible medical devices for MRI scans
Helyszínek itt: Egyesült Államok
- Dept. of Physical Therapy, East Carolina UniversityGreenville, Egyesült Államok
A vizsgálatról
Mit akar kideríteni a vizsgálat
Unilateral cerebral palsy (UCP) is a leading cause of childhood disability. An early brain injury impairs the upper extremity function, bimanual coordination, and impacts the child's independence. The existing therapeutic interventions have higher training doses and modest effect sizes. Thus, there is a critical need to find an effective priming agent to enhance bimanual skill learning in children with UCP. This study aims to determine the effects of a novel priming agent, remote ischemic conditioning (RIC), when paired with intensive bimanual skill training to enhance bimanual skill learning and to augment skill dependent plasticity in children with UCP.
A vizsgálat 2 csoportja
- Remote Ischemic Conditioning (RIC)A vizsgált kezelés
RIC is achieved via blood pressure cuff inflation to at least 20 mmHg above systolic blood pressure to 250 mmHg on the more involved arm. RIC involves 5 cycles of 5 minutes blood pressure cuff inflation followed by alternating 5 minutes of cuff deflation and requires 45 minutes. RIC is performed on visits 2-6. Intervention * Hand Arm Bimanual Intensive Therapy (HABIT) * Bimanual cup stacking training * Balance training
Kezelés: Remote Ischemic Conditioning (RIC), Hand Arm Bimanual Intensive Therapy (HABIT), Bimanual Cup Stacking Training és Balance training
- Sham ConditioningSzínlelt kezelés, összehasonlításként
Sham conditioning is achieved via blood pressure cuff inflation to 25 mmHg on the more involved arm. RIC involves 5 cycles of 5 minutes blood pressure cuff inflation followed by alternating 5 minutes of cuff deflation and requires 45 minutes. RIC is performed on visits 2-6. Intervention * Hand Arm Bimanual Intensive Therapy (HABIT) * Bimanual cup stacking training * Balance training
Kezelés: Sham conditioning, Hand Arm Bimanual Intensive Therapy (HABIT), Bimanual Cup Stacking Training és Balance training
Adatok és források
- Regiszteradat
- Szerepel a ClinicalTrials.gov-on.
- Hivatalos cím
- Effects of Remote Ischemic Conditioning on Bimanual Skill Learning, Bimanual Coordination, and Corticospinal Excitability in Children With Unilateral Cerebral Palsy
- A regiszteradat frissítve
- 2025. július 16.