Antidepressant Effects of Nitrous Oxide

Ki vehet részt

• Adult (≥18 years, both sexes)
• DSM-5 criteria for MDD without psychosis, as determined using a structured clinical interview [Mini International Neuropsychiatric Interview], MDD, defined by a pre-treatment score >16 on the HDRS-21 scale and meeting DSM-5 for MDD

Ki nem vehet részt

• Administration of NMDA-antagonists (e.g., ketamine) in previous 3 months
• Ongoing treatment with ECT
• Any contraindications to the use of nitrous oxide (e.g., pneumothorax, middle ear occlusion, elevated intracranial pressure, chronic cobalamin or folate deficiency unless treated with folic acid or vitamin B12)
• A current or past history of bipolar disorder, schizophrenia, or schizoaffective disorder
• Current obsessive-compulsive disorder, panic disorder, or documented Axis II diagnoses
• Active or recent (<12 months) substance use disorder; excluding nicotine
• Presence of acute medical illness that could interfere with study participation, including significant pulmonary disease
• Active suicidal intention, as determined by clinical interview assessment tool (Sheehan-STS) and clinical examination
• Pregnancy or breastfeeding