Effect of CPAP on Abnormal Gastroesophageal Reflux and Lung Inflammation in IPF
Megadott ok: Lack of enrollment
Key facts
- Where
- Tucson, Egyesült ÁllamokSee the site
Where in Egyesült Államok
- University of ArizonaTucson, Egyesült ÁllamokNo longer taking part
Trial details
- Who runs it
- University of Arizona
- Trial code
- NCT05359965
- Record updated
- 2026. március 9.
- Original description
This study will evaluate the effect of CPAP therapy on esophageal pH and lung inflammation in patients with idiopathic pulmonary fibrosis (IPF) and sleep apnea.Read full original descriptionShow less
Effect of Continuous Positive Airway Pressure (CPAP) on Abnormal Gastroesophageal Reflux and Lung Inflammation in Idiopathic Pulmonary Fibrosis (IPF)
This study will evaluate the effect of CPAP therapy on esophageal pH and lung inflammation in patients with idiopathic pulmonary fibrosis (IPF) and sleep apnea.
Inclusion: confirmed diagnosis of IPF based on the 2018 IPF guidelines; high likelihood of OSA based on the STOP-BANG measure, with a score of 3 or greater; patients on nintedanib, or in whom nintedanib will be initiated prior to enrollment in the study; able to participated in 24hr pH monitoring; able to comply with CPAP treatment; able to provide written informed consent prior to any study procedures; willing to complete all study measurements and assessments in compliance with the protocol.
Exclusion: severe concomitant illness limiting life expectancy (< 1 year); current drug or alcohol dependence; patients who have had prior nasal surgery or trauma that would make pH probe placement difficult; interstitial lung disease caused by conditions other than IPF; obstructive lung disease: FEV1/FVC ratio < 0.70; residual lung volume > or equal to 120% of predicted; patients who are unable to tolerate nintedanib; patients who are unable to use CPAP or are unwilling to participate in the 24 hr pH probe placement; patients who were diagnosed with recent IPF exacerbation within 4 weeks of enrollment (may be rescheduled for enrollment once recovered); patients on anticoagulation (aspirin is not an exclusion).