Splanchnic Venous Capacitance in Postural Tachycardia Syndrome
A legfontosabb adatok
- Hol
- Nashville (Egyesült Államok)A helyszín megnézése
- Fázis
- 2. fázis
Neked szólhat?
Magadról válaszolj. Ez nem döntés: hogy részt vehetsz-e, azt csak a vizsgálat csapata mondhatja meg.
- 18 és 50 év között vagy?
Forrás: NCT05375968: ki vehet részt
Helyszínek itt: Egyesült Államok
- Vanderbilt University Medical CenterNashville, Egyesült ÁllamokContact: Cyndya Shibao, MD, MSCIRésztvevőt keres
Kérdések a vizsgálat csapatának
- Milyen gyakran kell bejárnom, és egy-egy alkalom mennyi ideig tart?
- Megtérítik az utazási költséget?
- Megtarthatom a saját orvosomat?
- Mi történik, ha ki akarok lépni?
Contact the study team: see the registry record → Contacts and Locations
Oldal nyomtatása az orvosomnakA vizsgálat adatai
- Ki végzi
- Vanderbilt University Medical Center
- Azonosító
- NCT05375968
- A regiszteradat frissítve
- 2025. december 5.
- Eredeti leírás
Postural tachycardia syndrome (POTS) affects ≈3 million young people, characterized by chronic presyncopal symptoms characterized by dizziness, lightheadedness, and orthostatic tachycardia that occur while standing. Across-sectional survey found that 25% of these patients complains that meals rich in carbohydrates are among the factors that further exacerbate POTS's symptoms and cause a myriad of gastrointestinal symptoms.A teljes eredeti leírásKevesebb
Mechanism of Glucose-dependent Insulinotropic Polypeptide (GIP) on Splanchnic Venous Capacitance in Postural Tachycardia Syndrome
Postural tachycardia syndrome (POTS) affects ≈3 million young people, characterized by chronic presyncopal symptoms characterized by dizziness, lightheadedness, and orthostatic tachycardia that occur while standing. Across-sectional survey found that 25% of these patients complains that meals rich in carbohydrates are among the factors that further exacerbate POTS's symptoms and cause a myriad of gastrointestinal symptoms.
The splanchnic circulation is the largest blood volume reservoir of the human body, storing ≈25% of the total blood volume and contributing to sudden, and large, fluctuations in the stroke volume (SV). The orthostatic changes in systemic hemodynamics are particularly magnified after meals, due to increased blood volume sequestration triggered by the release of gastrointestinal peptides with vasodilatory properties. The purpose of this study is to determine if the worsening orthostatic tachycardia and symptoms after glucose ingestion in POTS patients are due to a greater increase in splanchnic venous capacitance and excessive blood pooling on standing as compare to Healthy controls.
The study will also determine if glucose-induced GIP secretion increases splanchnic venous capacitance, orthostatic tachycardia and worsening POTS postprandial symptoms. For this purpose subjects will be further randomized to either saline versus GIP(3-30)NH2 acute infusion, to measure the changes their splanchnic venous capacitance and superior mesenteric arterial flow before and after a 75-g oral glucose challenge during supine and 45-degree head-up tilt positions (orthostatic challenge) for up to 3 hours.
Bevonási feltételek: Between 18 and 50years of age; Cases: Diagnosis of POTS with presyncope symptoms after meals Or; Controls:; With no significant past medical history, non-smokers and not on chronic medications; Body mass index (BMI) between 18.5 to 29.9 kg/m2; If pre-menopausal women: must have regular menstrual cycle.
Kizáró feltételek: On statin therapy for high cholesterol; On oral corticosteroids,; Heart problems: myocardial infarction, angina, heart failure, stroke; Undergone any heart related procedures or stents or on pacemaker; Uncontrolled hypertension; Type 1 or type 2 diabetes mellitus; History of seizures; History of neck surgery; Current infections; BMI above ≥30 kg/m2; Irregular menstrual cycle; Intolerance to CPAP; Chronic use of acetaminophen; Pregnant or breast-feeding women; Impaired liver function; Impaired Kidney function test; Anemia (Hematocrit<34%); Ongoing substance abuse; Subjects with abnormal EKG; Diagnosed with neuropathy due to any reason; Smoker,; Rheumatoid arthritis; Documented of moderate decrease in blood volume.