Effect of Fetal Aortic Valvuloplasty on Outcomes

Ki vehet részt

• All of the following echocardiographic criteria need to be satisfied between 23+0 and 31+6 weeks (z-scores according to Schneider et al):
• Aortic valve stenosis with antegrade flow through the valve
• Predominantly left-to-right shunt at the atrial level
• Predominantly retrograde flow in the aortic arch between the first two brachiocephalic vessels
• Qualitatively depressed left ventricular function
• Left ventricular end-diastolic diameter Z-score > ±0
• Left ventricular inlet length in diastole :; Gestational age ≤ 24+6: Z-score > ±0; Gestational age 25+0 to 27+6: Z-score > -0.75; Gestational age ≥ 28+0: Z-score > -1.50
• Mitral valve diameter in diastole Z-score > -2.0
• All of the following postnatal treatment options need to be available: 1. Surgical or catheter based aortic valvotomy 2. Ross-Konno surgery 3. Norwood or hybrid stage-one surgery

Ki nem vehet részt

• Any associated cardiac defect except persistent left superior vena cava and coarctation of the aorta
• Any significant (i.e. that might influence outcome) extracardiac anomaly and/or known chromosomal aberration. Also, if such a condition is present at inclusion but diagnosed only after birth the case will be retrospectively excluded