Glecaprevir/Pibrentasvir for the Treatment of PTSD

Ki vehet részt

• Age 19-70 years
• Weight ≥ 45 kg
• PTSD as determined by the CAPS within seven days of enrollment
• Eligible for Veterans Affairs healthcare
• If of childbearing potential, use of acceptable method of birth control (i.e., effective contraceptives, abstinence) is required
• Able to read, understand, and sign the informed consent document

Ki nem vehet részt

• History of prior hepatic decompensation
• Current use of drugs listed as having significant drug interactions on prescribing label
• Current or prior hepatitis B infection
• Prior clinical use of GLE/PIB or HCV NS5A inhibitor AND NS3/4A protease inhibitor
• Evidence-based PTSD medication changes in the past two months
• Moderate or severe hepatic impairment (Child-Pugh B or C)
• Advanced liver disease
• Current HCV infection
• Unstable medical conditions
• Current severe alcohol or substance use disorder (excluding nicotine)
• Pregnant or lactating person
• Current psychosis or mania
• Significant suicidal ideation
• Evidence-based PTSD psychotherapy changes in the past two months