Neuromodulation of Memory in Aging

MI-összefoglaló

A vizsgálat saját részvételi feltételeiből. Gép olvasta ki az oldalon álló regiszterszövegből, ezért tévedhet. Hogy ki vehet részt, azt a lenti regiszterszöveg és a vizsgálat csapata dönti el.

The trial is looking for healthy older adults and people with mild cognitive impairment (MCI), a mild memory and thinking problem. It tests magnetic brain stimulation (TMS) on working memory.

Életkor

18 Years to 75 Years

Nem

All sexes can join

A betegség stádiuma

Healthy adults or people with mild cognitive impairment (MCI). People with dementia cannot join.

A részvétel fő kizáró okai

• Past mental health disorder of a major type (Axis I DSM-V), except major depression or generalized anxiety
• Current alcohol or drug abuse or dependence (nicotine is allowed)
• Implants in the head (such as clips, shunts, stimulators, cochlear implants), heart pacemaker or vagus nerve stimulator
• Higher risk of seizures, such as epilepsy, past seizures or head injury with loss of consciousness for ≥ 5 minutes
• Brain disorders such as stroke, fainting, brain aneurysm, dementia, Huntington chorea or multiple sclerosis, or medicines that make seizures more likely or affect memory

A regiszter feltételei, szó szerint

Nézd meg, megfelelhetsz-e

Magadról válaszolj. Ez nem döntés: hogy részt vehetsz-e, azt csak a vizsgálat csapata mondhatja meg.

• 18 és 75 év között vagy?IgenNem

Mit akar kideríteni a vizsgálat

The proposed research will use closed-loop transcranial magnetic stimulation (TMS) based on individualized brain networks to establish parameters that can reliably control brain states. This will be tested in healthy aging and mild cognitive impairment (MCI) cohorts. The investigators will study network activation and neural oscillatory mechanisms underlying the network that regulates working memory and then target this network using closed-loop TMS to the Prefrontal Cortex. Investigators will measure the impact of TMS on working memory performance and task-based neural activity. The project will use brain stimulation and network modeling techniques to enhance working memory in healthy older adults and MCI and will demonstrate the value of closed-loop, network-guided TMS for future clinical applications.

A vizsgálat 3 csoportja

• TMS-RandomizedA vizsgált kezelés

  Three different closed-loop conditions will be tested, each triggered by the presence of a sustained period of alpha-band power. In the first condition, arrhythmic TMS trains with a stochastic (randomized) inter-pulse interval, will be used to disrupt cortical alpha oscillations and thus be expected to enhance memory performance.

  Kezelés: Transcranial Magnetic Stimulation

• TMS-OrderedA vizsgált kezelés

  Three different closed-loop conditions will be tested, each triggered by the presence of a sustained period of alpha-band power. In the second condition, rhythmic (ordered) alpha-frequency TMS trains, with the expectation that this alpha stimulation will further entrain a synchronization during the task and thereby worsen memory performance.

  Kezelés: Transcranial Magnetic Stimulation

• TMS-ShamSzínlelt kezelés, összehasonlításként

  Three different closed-loop conditions will be tested, each triggered by the presence of a sustained period of alpha-band power. In a third condition, sham stimulation will be delivered at the same randomized inter-pulse interval, but with no TMS delivered to the brain.

  Kezelés: Transcranial Magnetic Stimulation