A Study of Brepocitinib in Adults With Active Non-Infectious Non-Anterior Uveitis

Ki vehet részt

• Adult subjects (18-74 years old)
• Diagnosis of non-infectious uveitis (intermediate uveitis, posterior uveitis, or panuveitis)
• Active uveitic disease as defined by the presence of at least 1 of the following parameters in at least 1 eye, as determined by the investigator:; Active, inflammatory chorioretinal and/or retinal vascular lesion; OR; ≥2+ vitreous haze grade (NEI/SUN criteria)
• Receiving up to one non-corticosteroid, non-biologic, immunomodulatory therapy
• Weight > 40 kg with a body mass index < 40 kg/m2

Ki nem vehet részt

• History of:; Any lymphoproliferative disorder; Active malignancy; History of cancer within 5 years prior to screening (exceptions for basal cell carcinoma, squamous cell carcinoma, ductal carcinoma in situ of the breast, carcinoma in situ of the uterine cervix, or thyroid carcinoma.)
• At risk of thrombosis and cardiovascular disease
• Have active or recent infections; Other protocol defined Inclusion/Exclusion criteria may apply
• Has isolated anterior uveitis
• Has confirmed or suspected current diagnosis of infectious uveitis
• Have a high risk for herpes zoster reactivation