Radiosurgery Induced Ototoxicity in Patients Treated for a Vestibular Schwannoma

MI-összefoglaló

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The trial is looking for adults with a vestibular schwannoma (a benign tumour on the hearing and balance nerve) on one side. They are treated with stereotactic radiosurgery or followed with MRI scans.

Életkor

18 years or older

Nem

All sexes

A betegség stádiuma

Vestibular schwannoma on one side only. The hospital's skull base tumour board chose radiosurgery or watching with MRI, separately from the study.

Korábbi kezelés

No earlier surgery or radiation for the vestibular schwannoma, including radiosurgery.

A részvétel fő kizáró okai

• Neurofibromatosis type II
• Severe hearing loss at the start (PTA >90 and WRS <10%)
• Earlier middle ear surgery on the affected ear
• Taking other experimental drugs at the same time
• Earlier surgery or radiation for the tumour

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

The investigators aim to study the impact of stereotactic radiosurgery, for the treatment of vestibular Schwannoma, on the cochlear, vestibular, gustatory, and facial nerve functions and compare it with a conservatively treated group. The predictive value of radiological tumor characteristics on hearing preservation and vestibular function will be also evaluated.

A vizsgálat 2 csoportja

• Stereotactic radiosurgery group

  Patients with unilateral Vestibular Schwannoma treated with stereotactic radiosurgery, as proposed by the institution's skull base tumor board independently of the study.

  Kezelés: Stereotactic radiosurgery

• Wait and scan group

  Patients with unilateral Vestibular Schwannoma followed with an MRI-based observation strategy, as proposed by the institution's skull base tumor board independently of the study.