Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD

Ki vehet részt

• Is a US Veteran
• Meets DSM-5 criteria for tobacco use disorder
• Is between the ages of 18 and 75
• Smokes an average of 10 cigarettes per day for the past 6 months, with carbon monoxide (CO) level > 6 ppm
• Is willing to attempt smoking cessation
• Meets DSM-5 criteria for current PTSD diagnosis
• Speaks, reads and writes English
• Is willing to sign a Duke consent for those portions of the study that occur at Duke
• Has been stable on psychotropic medications for at least three months

Ki nem vehet részt

• Has a contraindication to TMS or MRI; Personal or family history of a seizures or epilepsy; History of neurological condition that increases the risk of seizures including stroke or transient ischemic attack, cerebral aneurysm, or severe traumatic brain injury from a penetrating head injury, loss of consciousness > 20 minutes at time of traumatic injury, requiring an anticonvulsant medication for seizures, and/or found to have encephalomalacia on baseline MRI; Structural brain lesion, or prior brain surgery; Ferromagnetic metal in head (including shrapnel); Implanted devices that may be affected by MRI or TMS (pacemaker, medication pump, cochlear implant, implanted deep brain stimulator); Is pregnant (to be determined at Duke)
• Has previously received rTMS
• Has had a substance use disorder other than tobacco in the preceding 3 months
• Has a history of myocardial infarction in the past 6 months or has another contraindication to NRT
• Is unable to provide informed consent due to a major neurocognitive disorder or other reason
• Meets criteria for a primary psychotic disorder or current manic episode
• Is unable to complete study procedures
• Is currently prescribed bupropion and/or varenicline
• Uses other forms of nicotine such as cigars, pipes, chewing tobacco, or vaping
• Is currently imprisoned or psychiatrically hospitalized