European Study of Prodromal iNPH

Ki vehet részt

• Brain imaging with both:; Evans index > 0.3; Callosal angle ≤ 90 º or:; Disproportionately enlarged subarachnoid space hydrocephalus (DESH) - defined as: enlarged ventricles, dilated sylvian fissures and tight sulci at the high convexity
• Absence of symptoms or too mild symptoms to motivate shunt surgery according to local routine, and all of the following:; Normal gait pattern, or slight disturbance of the gait pattern that is not considered to be caused by a disease in the central nervous system (CNS); Gait velocity (maximum gait speed), men ≥ 1.4 m/s; women ≥ 1.25 m/s; Rombergs test with eyes open > 60 seconds; Mini Mental State Examination (MMSE) ≥ 27 or Montreal Cognitive Assessment (MoCA) ≥ 23
• Informed consent
• Age > 65 years
• iNPH diagnosis according to international guidelines.19
• Age matched with the individual in Group 1 (+/- 3 years)

Ki nem vehet részt

• Previously known relevant neurological disease
• Previous stroke (clinical stroke, not only radiologically verified)
• Other serious disease with expected survival less than three years
• Other serious disease with expected survival less than three years
• Contraindication for MRI
• Other type of hydrocephalus:; non-communicating hydrocephalus; secondary communicating hydrocephalus; suspected congenital hydrocephalus (severely enlarged ventricles, narrow sylvian fissures and normal non-compressed sulci at the high convexity or morphological findings consistent with PaVM18)
• Anticoagulants in a dose that hinders lumbar puncture
• Imaging findings meet inclusion criteria of Group 1
• Pathological gait pattern with unknown reason
• MMSE < 27 or MoCA < 26
• Anticoagulants in a dose that hinders lumbar puncture