Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis

MI-összefoglaló

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The trial is looking for adults with severe chronic rhinosinusitis (long-lasting swelling of the nose and sinuses) on both sides that is not under control. It is a registry that collects data from patients seen at specialist centres in Italy.

Életkor

18 Years and older

Nem

All sexes

A betegség stádiuma

Confirmed chronic rhinosinusitis on both sides. People who had sinus surgery need at least 3 of the listed signs; people who never had it need at least 4. Signs: type 2 inflammation, steroid tablet use, much worse quality of life (SNOT-22 >= 40 and/or Global VAS of symptoms >= 5), and loss of smell (VAS for hyposmia >= 7).

Korábbi kezelés

One of the listed signs is at least two short courses or long-term use of systemic corticosteroids (steroids taken by mouth or injection) for chronic rhinosinusitis. Earlier nasal sinus surgery changes how many signs are needed.

Biomarker vagy leletérték

One listed sign is type 2 inflammation: at least 250 blood eosinophils per microliter, and/or at least 10 eosinophils / HPF in a sinus tissue sample, and/or moderate eosinophilia on nasal cytology, and/or total serum IgE >100 IU / ml.

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

This observatory aims to collect, as widely as possible, the Italian cases of patients with uncontrolled CRS. Patient will be enrolled by the centers of the Italian Network of Rhinosinusitis (Rhinosinusitis Italian Network: RINET), and they will be treated using a multidisciplinary team approach (allergists, otolaryngologists and pneumologists) in a real-world clinical set-up.

A vizsgált kezelések

• Severe Uncontrolled Chronic Rhinosinusitis patients (CRS)