The Intervention of Psychobiotics in Patients With Anxiety Disorders

Ki vehet részt

• Age 20~70 years old
• Patients perceived that they had anxiety-related complaints, or with any type of anxiety disorders of adjustment disorders referred from the Departments of Psychiatry, Neurology, Internal Medicine, and Family Medicine in Mackay Memorial Hospital
• Adult GAD-7 ≥ 8 points (to screen for generalized anxiety disorder) or a DSM-5 diagnosis of generalized anxiety disorder (F41.1) or unspecified anxiety disorder (F41.9)
• Those who are currently under the treatment of selective serotonin reuptake inhibitors (SSRI) will only be included if their SSRI treatment has been stable or has not been changed for 4 weeks

Ki nem vehet részt

• Have taken antibiotics or are receiving antibiotic treatment within one month
• Patients who have undergone hepatobiliary gastrointestinal surgery (except for colorectal polypectomy and appendectomy)
• Patients with chronic psychiatric diseases who are currently taking drugs to treat acute diseases, organic brain diseases, or newly diagnosed or changed drugs within one month
• Those who are receiving parenteral nutrition
• Past or current patients with inflammatory bowel disease
• Those with a history of cancer
• Those who are allergic to lactic acid bacteria products
• Have used probiotic products in powder, capsule or tablet form within two weeks (excluding yogurt, Yakult and other related foods)
• Patients with severe depression (Patient Health Questionnaire-9 (PHQ-9) ≧ 20 points), or possible neurocognitive impairments (Mini-Mental States Examination (MMSE)<20), or those that had suicidal ideation noted on item 9 from PHQ-9
• Those who are evaluated by the principal investigator to be unsuitable to participate in the research