Therapeutic Ketogenic Diet in Anorexia Nervosa

Egyéb feltételek

• Weight-Recovered AN Inclusion Criteria:
• Provision of signed and dated informed consent form
• Stated willingness to comply with all study procedures and availability for the duration of the study
• Persons, aged 18 to 45 years
• History of anorexia nervosa according to DSM-5 criteria
• Weight recovered at the time of study inclusion (body mass index > 17.5 kg/m2)
• Greater or equal to 2 standard deviations scores of eating disorder-relevant behaviors on the Eating Disorder Inventory-3 and Eating Disorder Examination Questionnaire
• The following types of psychiatric medications are allowed: antidepressant, anxiolytic, atypical antipsychotic, mood stabilizers
• English is primary spoken language; Weight-Recovered AN Exclusion Criteria:
• Pregnancy or lactation
• Electrolyte, blood count, kidney function or liver function abnormalities
• Psychosis
• Neurocognitive disorders including dementias or traumatic brain injury that is symptomatic
• Current alcohol use disorder (AUD) or substance use disorder (SUD) according to DSM-5 criteria
• Uncontrolled hypertension
• Hepatic impairment (Class-Pugh b or c)
• Diabetes mellitus
• Family history of porphyria
• History of recent heart attack, vascular disease, or any other current acute medical conditions as determined by the principal investigator
• Inability or unwillingness to adhere to the TKD diet for the duration of the study
• Blind or illiterate individuals; Underweight AN Sub-Study Inclusion Criteria:
• Provision of signed and dated informed consent form
• Stated willingness to comply with all study procedures and availability for the duration of the study
• Persons, aged 18 to 45 years
• Anorexia nervosa according to DSM-5 criteria
• Current Body Mass Index (BMI) at the time of study inclusion of 16.0 to 17.49
• An elevated EDE-Q global score of 2.09 or greater
• The following types of psychiatric medications are allowed: antidepressant, anxiolytic, atypical antipsychotic, mood stabilizers
• English is primary spoken language; Underweight AN Sub-Study Exclusion Criteria:
• Pregnancy or lactation
• Electrolyte, blood count, kidney function or liver function abnormalities
• Psychosis
• Neurocognitive disorders including dementias or traumatic brain injury that is symptomatic
• Current alcohol use disorder (AUD) or substance use disorder (SUD) according to DSM-5 criteria
• Uncontrolled hypertension
• Hepatic impairment (Class-Pugh b or c)
• Diabetes mellitus
• Family history of porphyria
• History of recent heart attack, vascular disease, or any other current acute medical conditions as determined by the principal investigator
• Inability or unwillingness to adhere to the TKD diet for the duration of the study
• Blind or illiterate individuals; Bulimia Nervosa Pilot Inclusion Criteria:
• Provision of signed and dated informed consent form
• Stated willingness to comply with all study procedures and availability for the duration of the study
• Persons, aged 18 to 45 years
• History of bulimia nervosa according to DSM-5 criteria
• An elevated EDE-Q global score of 2.09 or greater
• The following types of psychiatric medications are allowed: antidepressant, anxiolytic, atypical antipsychotic, mood stabilizers
• English is primary spoken language; Bulimia Nervosa Pilot Exclusion Criteria:
• Pregnancy or lactation
• Electrolyte, blood count, kidney function or liver function abnormalities
• Psychosis
• Neurocognitive disorders including dementias or traumatic brain injury that is symptomatic
• Current alcohol use disorder (AUD) or substance use disorder (SUD) according to DSM-5 criteria
• Uncontrolled hypertension
• Hepatic impairment (Class-Pugh b or c)
• Diabetes mellitus
• Family history of porphyria
• History of recent heart attack, vascular disease, or any other current acute medical conditions as determined by the principal investigator
• Inability or unwillingness to adhere to the TKD diet for the duration of the study
• Blind or illiterate individuals