The Scottish Aortic Stenosis LongiTudinal Imaging and biomarkeR (SALTIRE) Programme
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Contact the study team: see the registry record → Contacts and Locations
Oldal nyomtatása az orvosomnakA vizsgálat adatai
- Ki végzi
- University of Edinburgh
- Azonosító
- NCT06047561
- A regiszteradat frissítve
- 2026. szeptember 21.
- Eredeti leírás
The goal of this observational study is to understand the processes of what causes and accelerates the disease progress in aortic stenosis and following aortic valve replacement.A teljes eredeti leírásKevesebb
The goal of this observational study is to understand the processes of what causes and accelerates the disease progress in aortic stenosis and following aortic valve replacement.
Participants will undergo transthoracic echocardiography every 6 months, with annual visits for state-of-the-art scanning techniques including positron-emission tomography combined with computed tomography or magnetic resonance imaging with radiotracers designed to look at disease processes including fibrosis, calcification, inflammation and thrombosis activity.
Bevonási feltételek: Male or female aged >50 years; Provision of informed consent prior to any study specific procedures; Patients with bioprosthetic aortic valve replacements, including both surgically and transcatheter implanted valves; Patients with severe aortic stenosis (peak velocity >4.0 m/s; previously recruited patients); Patients with moderate aortic stenosis (peak velocity 3.0-4.0 m/s; new prospectively recruited patients); Patients with mild aortic stenosis (peak velocity 2.5-2.9 m/s; new prospectively recruited patients); Patients with aortic sclerosis (tri-leaflet thickened aortic valve with no obstruction of ventricular outflow); Age and sex-matched healthy volunteers.
Kizáró feltételek: Those with an allergy to iodinated contrast; Patients with known Rheumatic Heart Disease; Patients with impaired renal function (eGFR of <30 mL/min/1.73m2); Inability or unwilling to give informed consent; Women who are pregnant or breastfeeding; Patients with known Ochronosis; Patients with known Familial Homozygous Hypercholesterolaemia.